Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma

Imakura, Takeshi; Sato, Seidai; Tomonari, Tetsu; Murakami, Kojin; Takahashi, Naoki; Naito, Nobuhito; Mima, Masato; Kagawa, Kozo; Koyama, Kazuya; Nishimura, Haruka; Kawano, Hiroshi; Nokihara, Hiroshi; Azuma, Masahiko; Takayama, Tetsuji; Nishioka, Yasuhiko

doi:10.2169/internalmedicine.7300-21

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Use this link to cite this item : https://repo.lib.tokushima-u.ac.jp/118011

ID	118011
Author	Imakura, Takeshi Tokushima University Sato, Seidai Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers Tomonari, Tetsu Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers Murakami, Kojin Tokushima University Takahashi, Naoki Tokushima University Naito, Nobuhito Tokushima University Tokushima University Educator and Researcher Directory Mima, Masato Tokushima University Kagawa, Kozo Tokushima University Tokushima University Educator and Researcher Directory Koyama, Kazuya Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers Nishimura, Haruka Tokushima University Kawano, Hiroshi Tokushima University Tokushima University Educator and Researcher Directory Nokihara, Hiroshi Tokushima University Azuma, Masahiko Tokushima University KAKEN Search Researchers Takayama, Tetsuji Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers Nishioka, Yasuhiko Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords	lenvatinib interstitial pneumonia hepatocellular carcinoma
Content Type	Journal Article
Description	Lenvatinib is a multi-targeted tyrosine kinase inhibitor available for the treatment of unresectable hepatocellular carcinoma (HCC). We herein report an 84-year-old-man with interstitial pneumonia caused by lenvatinib. Four months after the start of lenvatinib administration for HCC, chest computed tomography revealed bilateral ground-glass opacity. However, he continued to take lenvatinib for four more months until he complained of dyspnea on exertion. This is a case of lenvatinib-induced interstitial pneumonia that progressed relatively slowly with a long asymptomatic period despite the appearance of pneumonia on image findings.
Journal Title	Internal Medicine
ISSN	13497235
Publisher	The Japanese Society of Internal Medicine
Volume	61
Issue	8
Start Page	1211
End Page	1217
Published Date	2022-04-15
Rights	The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID	387289
DOI (Published Version)	10.2169/internalmedicine.7300-21
URL ( Publisher's Version )	https://doi.org/10.2169/internalmedicine.7300-21
FullText File	internalmedicine_61_8_1211.pdf 1020 KB
language	eng
TextVersion	Publisher
departments	University Hospital Medical Sciences