大腸癌肺転移切除例の予後因子の検討

The objective of this study was to evaluate prognostic factors after pulmonary resection for metastasis of colorectal cancer. We retrospectively analyzed the clinicopathological factors and the prognosis of 36patients who received pulmonary resection for metastasis of colorectal cancer. The 5-year overall survival after pulmonary resection was 75.4％, and the 3-year disease free survival after pulmonary resection was 53.5％. There was no significant prognostic factor regarding overall survival after pulmonary resection by multivariate analysis. However, regarding disease-free survival after pulmonary resection, T4 stage colorectal cancer showed significant poorer prognosis by multivariate analysis（p＝0.014）. Patients who received reoperation for pulmonary recurrence showed better prognosis than patients who did not receive reoperation (p＝ 0.04). Prognosis after pulmonary resection for metastasis of colorectal cancer is favorable owing to progresses of chemotherapies.
Metastasectomy may not be the primary therapy for patients with pulmonary metastasis from T4 stage colorectal cancer because of their short disease-free survival after metastasectomy. Reoperation for resectable recurrence of pulmonary metastasis may improve overall survival.