ID | 110928 |
Title Alternative | 心エコー図検査で計測した心外膜下脂肪厚は誘発試験中の症候性冠攣縮と関連する
|
Author |
Nishio, Susumu
Tokushima University
Kusunose, Kenya
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Yamada, Hirotsugu
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Hirata, Yukina
Tokushima University
Ise, Takayuki
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Yamaguchi, Koji
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Yagi, Shusuke
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Soeki, Takeshi
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Wakatsuki, Tetsuzo
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Sata, Masataka
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
|
Keywords | Echocardiography
Epicardial adipose tissue
Vasospasm in patients with angina
Anterior interventricular groove
|
Content Type |
Thesis or Dissertation
|
Description | Background: Epicardial adipose tissue (EAT) is the ectopic visceral fat surrounding the heart, which plays an important role in atherosclerosis of the coronary arteries via endothelial damage. Several studies have also suggested that vasospasmwith angina (VSA) causes endothelial dysfunction in the coronary arteries. The aimof this study was to evaluate the thickness of EAT in the anterior interventricular groove (EAT-AIG) using echocardiography in patients who had no obstructive coronary artery disease and were suspected of having VSA.
Methods: Sixty-five patients who underwent intracoronary acetylcholine provocation testing for clinical indications were prospectively enrolled. VSA was diagnosed by coronary artery stenosis increase of >90% and the presentation of chest pain with ischemic changes on electrocardiography. Results: Subjects were divided into two groups, with and without significant coronary spasm (VSA group, 30 patients; non-VSA group, 35 patients), consistent with acetylcholine provocation testing. EAT-AIG thickness was significantly greater in the VSA group than in the non-VSA group (8.2±2.7 vs 6.1±2.5 mm, P = .002). By receiver operating characteristic analysis, EAT-AIG thickness had a high C statistic (area under the curve = 0.81, P < .001) after adjustment for conventional risk factors (smoking, diabetes mellitus, and dyslipidemia). EAT-AIG thickness had incremental diagnostic value over other conventional risk factors (area under the curve = 0.81 vs 0.64, P for comparison = .020). Conclusions: EAT-AIG thickness, which is noninvasively and easily measured using transthoracic echocardiography, can be one of multiple clinical variables associated with VSA. |
Journal Title |
Journal of the American Society of Echocardiography
|
ISSN | 08947317
|
NCID | AA10709494
|
Publisher | The American Society of Echocardiography|Elsevier
|
Volume | 30
|
Issue | 10
|
Start Page | 1021
|
End Page | 1027.e1
|
Published Date | 2017-08-23
|
Remark | 内容要旨・審査要旨・論文本文の公開
本論文は, 著者Susumu Nishioの学位論文として提出され, 学位審査・授与の対象となっている。 |
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
|
TextVersion |
ETD
|
MEXT report number | 甲第3104号
|
Diploma Number | 甲医第1348号
|
Granted Date | 2017-09-28
|
Degree Name |
Doctor of Medical Science
|
Grantor |
Tokushima University
|
departments |
University Hospital
Medical Sciences
|