ID | 113221 |
Title Alternative | Combined Predictors for AF
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Author |
Soeki, Takeshi
Tokushima University
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Matsuura, Tomomi
Tokushima University
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Bando, Sachiko
Tokushima University
Matsumoto, Kazuhisa
Tokushima University
Nagano, Hiromi
Tokushima University
Uematsu, Etsuko
Tokushima University
Kusunose, Kenya
Tokushima University
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Ise, Takayuki
Tokushima University
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Yamaguchi, Koji
Tokushima University
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Yagi, Shusuke
Tokushima University
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Yamada, Hirotsugu
Tokushima University
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Wakatsuki, Tetsuzo
Tokushima University
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Sata, Masataka
Tokushima University
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|
Keywords | Atrial fibrillation
Left atrial diameter
Premature atrial contraction
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Content Type |
Journal Article
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Description | Background: The ability to identify risk markers for new-onset atrial fibrillation (AF) is critical to the development of preventive strategies, but it remains unknown whether a combination of clinical, electrocardiographic, and echocardiographic parameters predicts the onset of AF. In the present study, we evaluated the predictive value of a combined score that includes these parameters.
Methods and Results: We retrospectively studied 1,040 patients without AF who underwent both echocardiography and 24-h Holter electrocardiography between May 2005 and December 2010. During a median follow-up period of 68.4 months (IQR, 49.9–93.3 months), we investigated the incidence of new-onset AF. Of the 1,040 patients, 103 (9.9%) developed AF. Patients who developed AF were older than patients who did not. Total heart beats, premature atrial contraction (PAC) count, maximum RR interval, and frequency of sinus pause quantified on 24-h electrocardiography were associated with new-onset AF. LA diameter (LAD) on echocardiography was also associated with the development of AF. On multivariate Cox analysis, age ≥58 years, PAC count ≥80 beats/day, maximum RR interval ≥1.64 s, and LAD ≥4.5 cm were independently associated with the development of AF. The incidence rate of new-onset AF significantly increased as the combined score (i.e., the sum of the risk score determined using hazard ratios) increased. Conclusions: A combined score that includes age, PAC count, maximum RR interval, and LAD could help characterize the risk of new-onset AF. |
Journal Title |
Circulation Journal
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ISSN | 13469843
13474820
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NCID | AA11591968
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Publisher | The Japanese Circulation Society
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Volume | 82
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Issue | 9
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Start Page | 2253
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End Page | 2258
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Published Date | 2018-05-30
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
Medical Sciences
University Hospital
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