ID | 115937 |
Title Alternative | 高血圧患者におけるアンジオテンシン II-レニンフィードバック機構に対するL/N型カルシウムチャネル拮抗薬の影響
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Author |
Kawabata, Yutaka
Tokushima University
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Soeki, Takeshi
Tokushima University
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Matsuura, Tomomi
Tokushima University
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Kusunose, Kenya
Tokushima University
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Ise, Takayuki
Tokushima University
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Yamaguchi, Koji
Tokushima University
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Yagi, Shusuke
Tokushima University
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Yamada, Hirotsugu
Tokushima University
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Wakatsuki, Tetsuzo
Tokushima University
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Kitani, Mitsuhiro
Kagawa Prefectural Shirotori Hospital
Kawano, Kazuhiro
Yoshinogawa Medical Center
Sata, Masataka
Tokushima University
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Keywords | L-/N-type calcium channel blocker
renoprotective effect
suppressing renin-angiotensin system
the ratio of Angiotensin-(1–7)/Angiotensin II
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Content Type |
Thesis or Dissertation
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Description | Objectives. Cilnidipine, an L-/N-type calcium channel blocker (CCB), has unique organ-protective properties due to suppression of hyperactivity in the sympathetic nervous system and renin-angiotensin system (RAS). In this study, we hypothesized that cilnidipine might exert a renoprotective effect by suppressing the RAS.
Methods. A total of 25 hypertensive patients receiving a RAS inhibitor were randomly assigned to a cilnidipine (n = 12) or amlodipine (n = 13) group. The effects of cilnidipine on proteinuria and angiotensin II–renin feedback were assessed. Results. After 6 months of treatment, both systolic and diastolic blood pressures were significantly reduced to a similar extent in both groups. The urine albumin-to-creatinine ratio was significantly lower in the cilnidipine group (p < 0.05) than in the amlodipine group. Amlodipine increased plasma angiotensin I and angiotensin II levels (p < 0.05), whereas cilnidipine did not. Interestingly, the cilnidipine group had a higher ratio of angiotensin-(1–7) (Ang-(1–7)) to angiotensin II in plasma than the amlodipine group (p < 0.05). Conclusions. The L-/N-type CCB cilnidipine, but not amlodipine, decreased urinary albumin excretion in hypertensive patients. Cilnidipine also increased the ratio of Ang-(1–7) to angiotensin II in plasma, which might be one factor underlying its beneficial effects. |
Journal Title |
International Journal of Hypertension
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ISSN | 20900384
20900392
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Publisher | Hindawi
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Volume | 2020
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Start Page | 6653851
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Published Date | 2020-12-22
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Remark | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Yutaka Kawabataの学位論文として提出され,学位審査・授与の対象となっている。 |
Rights | Copyright © 2020 Yutaka Kawabata et al.
This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第3478号
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Diploma Number | 甲医第1480号
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Granted Date | 2021-02-25
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Degree Name |
Doctor of Medical Science
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Grantor |
Tokushima University
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departments |
University Hospital
Medical Sciences
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