ID | 111182 |
Title Alternative | resting state functional MRIによる自閉性障害若年者におけるdefault mode networkの変化に関する検討
Alteration of default mode network in children with autism spectrum disorder
|
Author |
Funakoshi, Yasuhiro
University of Tokushima
Harada, Masafumi
University of Tokushima
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Otsuka, Hideki
University of Tokushima
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Mori, Kenji
University of Tokushima
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Iwanaga, Takashi
University of Tokushima
|
Keywords | default mode network
resting state MRI
autism spectrum disorder
interior parietal lobule
posterior cingulate cortex
development
|
Content Type |
Thesis or Dissertation
|
Description | Purpose : The purpose of this study was to investigate changes in the functional connectivity of the default mode network (DMN) in normal aging and in children with autistic spectrum disorder (ASD) by using resting-state functional magnetic resonance imaging (rsfMRI) and independent component analysis. Methods : Thirty-one healthy controls (HC) in four age groups (1-3, 4-8, 20-29, and 50-59 years) and 14 childhood ASD cases (1-8 years of age) were examined by rsfMRI echo-planar imaging on a clinical 3-T MRI scanner. Imaging of all children (1-8 years) was conducted under sedation, while adults were scanned in the awake state with eyes closed. Results : The regions of DMN functional connectivity in the bilateral inferior parietal lobule and posterior cingulate cortex were smaller in HC children than in HC adults, and smaller in the ASD group than in the HC children. Conclusion : It is possible to observe developmental and pathological changes in the DMN by rsfMRI. Reduced DMN functional connectivity in children may be a useful biomarker for ASD diagnosis.
|
Journal Title |
The Journal of Medical Investigation
|
ISSN | 13496867
13431420
|
NCID | AA11166929
AA12022913
|
Publisher | Faculty of Medicine Tokushima University
|
Volume | 63
|
Issue | 3-4
|
Start Page | 204
|
End Page | 208
|
Sort Key | 204
|
Published Date | 2016-08
|
Remark | 内容要旨・審査要旨・論文本文の公開:
内容要旨 : LID201701261003.pdf 審査要旨 : LID201701261004.pdf 論文本文 : LID201701261005.pdf 本論文は,著者Yasuhiro Funakoshiの学位論文として提出され,学位審査・授与の対象となっている。 |
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
|
TextVersion |
ETD
|
MEXT report number | 甲第3004号
|
Diploma Number | 甲保第25号
|
Granted Date | 2016-12-15
|
Degree Name |
Doctor of Health Science
|
Grantor |
Tokushima University
|
departments |
Medical Sciences
|