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ID 118205
Title Alternative
膵内副脾発生類表皮嚢胞の発生機序・組織学的特徴に関する検討
Histological analysis of ECIPAS
Author
Sumida, Satoshi Tokushima University
Miyakami, Yuko Tokushima University
Kakimoto, Takumi Tokushima University
Kobayashi, Tomoko Tokushima University
Taira, Shu Fukushima University
Keywords
Epidermoid cyst in intrapancreatic accessory spleen
imaging mass spectrometry
lipid excretion
Pbx1
Tlx1
Content Type
Thesis or Dissertation
Description
Background : Epidermoid cysts in intrapancreatic accessory spleen (ECIPAS) are a rare lesion. Its pathogenesis, including the origin of cystic epithelium, is not well established. We aimed to elucidate new aspects of the pathological features of ECIPAS to clarify its pathogenesis. Methods : Six cases of ECIPAS were included in this study. As well as histopathological analysis, to elucidate the features and nature of cystic epithelial cells, immunohistochemical analysis including Pbx1 and Tlx1 and imaging mass spectrometry was performed. Results : Histologically, the cysts were covered by either monolayered or multilayered epithelium. Immunohistochemistry revealed that the epithelial cells in multilayered epithelium exhibited different attributes between the basal and superficial layers. Few epithelial cells had abundant clear cytoplasm and were immunohistochemically positive for adipophilin, suggesting lipid-excreting function. The intracystic fluid contained cholesterol clefts and foamy macrophages, and imaging mass spectrometry revealed the accumulation of lipids. Immunohistochemical analysis indicated that the epithelial cells were positive for Pbx1 in some cases. Conclusion : Novel histological features of epithelial cells of ECIPAS were indicated. Although more cases need to be evaluated, we propose that the cause of ECIPAS may be different from that of pancreatic ductal origin.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
70
Issue
1-2
Start Page
251
End Page
259
Sort Key
251
Published Date
2023-02
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Satoshi Sumidaの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3702号
Diploma Number
甲医第1572号
Granted Date
2023-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital