ID | 116888 |
Title Alternative | ベタヒスチンが一側内耳破壊後のラットの前庭代償に与える影響
|
Author |
Fukuda, Junya
University of Tokushima
Satou, Go
University of Tokushima
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Kitahara, Tadashi
Nara Medical University
Matsuoka, Momoyo
University of Tokushima
Azuma, Takahiro
University of Tokushima
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Kitamura, Yoshiaki
University of Tokushima
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Takeda, Noriaki
University of Tokushima
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
|
Keywords | vestibular compensation
betahistine dihydrochloride
medial vestibular nucleus
Fos
histamine H3 receptor
|
Content Type |
Thesis or Dissertation
|
Description | Background: Vestibular compensation (VC) after unilateral labyrinthectomy (UL) consists of the initial and late processes. These processes can be evaluated based on the decline in the frequency of spontaneous nystagmus (SN) and the number of MK801-induced Fos-positive neurons in the contralateral medial vestibular nucleus (contra-MVe) in rats. Histamine H3 receptors (H3R) are reported to be involved in the development of VC. Objective: We examined the effects of betahistine, an H3R antagonist, on the initial and late processes of VC in UL rats. Methods: Betahistine dihydrochloride was continuously administered to the UL rats at doses of 100 and 200 mg/kg/day using an osmotic minipump. MK801 (1.0 mg/kg) was intraperitoneally administered on days 7, 10, 12, and 14 after UL, while Fos-positive neurons were immunohistochemically stained in the contra-MVe. Results: The SN disappeared after 42 h, and continuous infusion of betahistine did not change the decline in the frequency of SN. The number of MK801-induced Fos-positive neurons in contra-MVe significantly decreased on days 7, 10, and 12 after UL in a dose-dependent manner in the betahistine-treated rats, more so than in the saline-treated rats. Conclusion: These findings suggest that betahistine facilitated the late, but not the initial, process of VC in UL rats.
|
Journal Title |
Brain Sciences
|
ISSN | 20763425
|
Publisher | MDPI
|
Volume | 11
|
Issue | 3
|
Start Page | 360
|
Published Date | 2021-03-11
|
Remark | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Junya Fukudaの学位論文として提出され,学位審査・授与の対象となっている。 |
Rights | © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/ ). |
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
|
TextVersion |
ETD
|
MEXT report number | 甲第3591号
|
Diploma Number | 甲医第1519号
|
Granted Date | 2022-03-23
|
Degree Name |
Doctor of Medical Science
|
Grantor |
Tokushima University
|
departments |
University Hospital
Medical Sciences
|