ID | 118271 |
Title Alternative | L型アミノ酸輸送体3が肝細胞癌の予後に与える影響
IMPACT OF LAT3 ON HCC
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Author |
Baasansuren, Selenge
Tokushima University
Yamada, Shinichiro
Tokushima University
Tokushima University Educator and Researcher Directory
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Morine, Yuji
Tokushima University
Tokushima University Educator and Researcher Directory
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Ikemoto, Tetsuya
Tokushima University
Tokushima University Educator and Researcher Directory
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Saito, Yu
Tokushima University
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Takasu, Chie
Tokushima University
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Keywords | LAT3
HCC
amino acid
leucine
p‑AKT
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Content Type |
Thesis or Dissertation
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Description | The aim of the present study was to investigate the impact of L‑type amino acid transporter 3 (LAT3) expression on the prognosis of hepatocellular carcinoma (HCC). A total of 135 patients who had undergone initial hepatic resection for HCC at Tokushima University Hospital (Tokushima, Japan) were enrolled in the present study. Immunohistochemical analysis of LAT3 and phosphorylated AKT (p‑AKT) was performed using resected specimens. Clinicopathological factors, including prognosis, were compared between the LAT3‑high and ‑low expression groups. The results demonstrated that the LAT3‑high group showed significantly higher protein induced by vitamin K absence‑II levels (P=0.01) compared with the LAT3‑low group. The LAT3‑high group showed significantly worse prognosis compared with the LAT3‑low group regarding cancer‑specific survival and disease‑free survival (P<0.05). Multivariate analysis revealed that high LAT3 expression and multiple tumors were independent prognostic factors for cancer‑specific survival. Furthermore, the rate of p‑AKT‑positive cases was higher in the LAT3‑high group than in the LAT3‑low group. Overall, these findings suggested that LAT3 expression was associated with poor prognosis of HCC and high p‑AKT expression.
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Journal Title |
Oncology Letters
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ISSN | 17921074
17921082
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Publisher | Spandidos Publications
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Volume | 24
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Issue | 5
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Start Page | 418
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Published Date | 2022-09-30
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Remark | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Baasansuren Selengeの学位論文として提出され,学位審査・授与の対象となっている。 著者名英表記誤記あり (誤)BAASANSVREN SELENGE→(正)BAASANSUREN SELENGE |
Rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.( https://creativecommons.org/licenses/by-nc-nd/4.0/ )
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第3691号
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Diploma Number | 甲医第1556号
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Granted Date | 2023-03-23
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Degree Name |
Doctor of Medical Science
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Grantor |
Tokushima University
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departments |
University Hospital
Medical Sciences
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