| ID | 110791 |
| Author |
Otsuka, Toshihiro
Department of Digestive and Pediatric Surgery, Institute of Health Biosciences ,The University of Tokushima Graduate School
Izumi, Keisuke
Department of Molecular and Environmental Pathology, Institute of Health Biosciences ,The University of Tokushima Graduate School
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Tokunaga, Itsuo
Department of Legal Medicine, Institute of Health Biosciences ,The University of Tokushima Graduate School
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Gotohda, Takako
Department of Legal Medicine, Institute of Health Biosciences ,The University of Tokushima Graduate School
Ipposhi, Kaneshige
Department of Clinical Pharmacology, Institute of Health Biosciences ,The University of Tokushima Graduate School
Takiguchi, Yoshiharu
Department of Clinical Pharmacology, Institute of Health Biosciences ,The University of Tokushima Graduate School
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Kaneda, Shinya
Department of Molecular and Environmental Pathology, Institute of Health Biosciences ,The University of Tokushima Graduate School
Satake, Nobuo
Department of Molecular and Environmental Pathology, Institute of Health Biosciences ,The University of Tokushima Graduate School
Ohnishi, Takamasa
Department of Molecular and Environmental Pathology, Institute of Health Biosciences ,The University of Tokushima Graduate School
Tashiro, Seiki
Department of Digestive and Pediatric Surgery, Institute of Health Biosciences ,The University of Tokushima Graduate School
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Shimada, Mitsuo
Department of Digestive and Pediatric Surgery, Institute of Health Biosciences ,The University of Tokushima Graduate School
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|
| Keywords | LEC rat
8-OHdG
glutathione peroxidase
D-galactosamine hydrochloride
Wilson’s disease
|
| Content Type |
Journal Article
|
| Description | Repeated injections of D-galactosamine hydrochloride (GalN) increase the survival rate of Long-Evans Cinnamon (LEC) rats, an animal model of Wilson’s disease. The aim of the present study was to investigate the mechanism of GalN for prevention of spontaneous lethal hepatic injury in LEC rats. MaleLEC rats were given a single subcutaneous injection of 300mg/kg of GalN or vehicle (0.9%NaCl) at 14weeks, and killed at 28 weeks of age. Next, 6-week-old male LEC rats were given weekly subcutaneous injections of 300 mg/kg of GalN or vehicle for 3 or 12 weeks, and their hepatic 8-hydroxydeoxy-2’-guanosine (8-OHdG), glutathione peroxidase (GPX), and catalase activities were measured. None of GalN-treated rats died of hepatic injury (0/12), whereas the mortality rate of control rats given 0.9% NaCl was 17% (2/12). GalN administration for 12 weeks decreased the hepatic 8-OHdG, and GalN administration for either 3 or 12weeks increased the glutathione peroxidase activity. GalN administration increased the serum level of alanine aminotransferase, and accelerated megalocytic degeneration of the hepatocytes. GalN treatment is effective in preventing lethal hepatitis in LEC rats and decrease of oxidative DNA damage by GalN plays an important role in increase of the survival rate.
|
| Journal Title |
The journal of medical investigation : JMI
|
| ISSN | 13431420
|
| NCID | AA11166929
|
| Volume | 53
|
| Issue | 1-2
|
| Start Page | 81
|
| End Page | 86
|
| Sort Key | 81
|
| Published Date | 2006-02
|
| EDB ID | |
| FullText File | |
| language |
eng
|
| TextVersion |
Publisher
|
| departments |
Pharmaceutical Sciences
Medical Sciences
University Hospital
|
