ID | 114461 |
Title Alternative | Drug Repositioning for Cardiac Arrest
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Author |
Niimura, Takahiro
Tokushima University
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Koyama, Toshihiro
Okayama University
Shigemi, Yuta
Okayama University
Izawa-Ishizawa, Yuki
Tokushima University
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Morita, Mizuki
Okayama University
Ohshima, Ayako
Okayama University
Harada, Keisaku
Kitakyushu City Yahata Hospital
Imai, Toru
Nihon University
Hagiwara, Hiromi
Nagoya City University
Goda, Mitsuhiro
Tokushima University
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Takechi, Kenshi
Tokushima University
Chuma, Masayuki
Tokushima University
Kondo, Yutaka
Juntendo University
Tsuchiya, Koichiro
Tokushima University
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Hinotsu, Shiro
Sapporo Medical University
Kano, Mitsunobu R.
Okayama University
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Keywords | cardiac arrest
drug repositioning
claims database
drug discovery tool
vasodilator
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Content Type |
Journal Article
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Description | The survival rate of cardiac arrest patients is less than 10%; therefore, development of a therapeutic strategy that improves their prognosis is necessary. Herein, we searched data collected from medical facilities throughout Japan for drugs that improve the survival rate of cardiac arrest patients. Candidate drugs, which could improve the prognosis of cardiac arrest patients, were extracted using “TargetMine,” a drug discovery tool. We investigated whether the candidate drugs were among the drugs administered within 1 month after cardiac arrest in data of cardiac arrest cases obtained from the Japan Medical Data Center. Logistic regression analysis was performed, with the explanatory variables being the presence or absence of the administration of those candidate drugs that were administered to ≥10 patients and the objective variable being the “survival discharge.” Adjusted odds ratios for survival discharge were calculated using propensity scores for drugs that significantly improved the proportion of survival discharge; the influence of covariates, such as patient background, medical history, and treatment factors, was excluded by the inverse probability-of-treatment weighted method. Using the search strategy, we extracted 165 drugs with vasodilator activity as candidate drugs. Drugs not approved in Japan, oral medicines, and external medicines were excluded. Then, we investigated whether the candidate drugs were administered to the 2,227 cardiac arrest patients included in this study. The results of the logistic regression analysis showed that three (isosorbide dinitrate, nitroglycerin, and nicardipine) of seven drugs that were administered to ≥10 patients showed significant association with improvement in the proportion of survival discharge. Further analyses using propensity scores revealed that the adjusted odds ratios for survival discharge for patients administered isosorbide dinitrate, nitroglycerin, and nicardipine were 3.35, 5.44, and 4.58, respectively. Thus, it can be suggested that isosorbide dinitrate, nitroglycerin, and nicardipine could be novel therapeutic agents for improving the prognosis of cardiac arrest patients.
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Journal Title |
Frontiers in Pharmacology
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ISSN | 16639812
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Publisher | Frontiers Media S.A.
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Volume | 10
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Start Page | 1257
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Published Date | 2019-11-08
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Rights | Copyright © 2019 Zamami, Niimura, Koyama, Shigemi, Izawa-Ishizawa, Morita, Ohshima, Harada, Imai, Hagiwara, Okada, Goda, Takechi, Chuma, Kondo, Tsuchiya, Hinotsu, Kano and Ishizawa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). (https://creativecommons.org/licenses/by/4.0/) The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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language |
eng
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Publisher
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departments |
Medical Sciences
Pharmaceutical Sciences
University Hospital
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