ID | 114361 |
Author |
Yoshimoto, Katsuhiko
The University of Tokushima
Tokushima University Educator and Researcher Directory
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Iwahana, Hiroyuki
The University of Tokushima
Fukuda, Ayumi
The University of Tokushima
Sano, Toshiaki
The University of Tokushima
Tokushima University Educator and Researcher Directory
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Katsuragi, Kiyonori
Otsuka Assay Laboratories
Kinoshita, Moritoshi
Otsuka Assay Laboratories
Saito, Shiro
The University of Tokushima
Itakura, Mitsuo
The University of Tokushima
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Keywords | ras Gene
Missense mutation
Thyroid follicular adenoma
Pheochromocytoma
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Content Type |
Journal Article
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Description | To elucidate the molecular basis for endocrine tumorigenesis, ras mutations in human endocrine tumors were analyzed using polymerase chain reaction‐single strand conformation polymorphism (PCR‐SSCP) analysis. Mutations of the H‐, K‐, N‐ras genes were examined in genomic DNAs from 169 successfully amplified primary endocrine tumors out of 189 samples. Four out of 24 thyroid follicular adenomas analyzed contained mutated N‐ras codon 61, and one contained the mutated H‐ras codon 61. One of the 19 pheochromocytomas revealed mutation of the H‐ras codon 13. No mutations of the ras gene were detected in pituitary adenomas, parathyroid tumors, thyroid cancers, endocrine pancreatic tumors, and adrenocortical tumors. Based on these findings we conclude that activation of the ras gene may play a role in the tumorigenesis of a limited number of thyroid follicular adenomas and pheochromocytomas, and that mutation of the ras gene is not frequent in other human endocrine tumors.
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Journal Title |
Japanese Journal of Cancer Research
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NCID | AA00690844
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Publisher | Japanese Cancer Association|John Wiley & Sons
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Volume | 83
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Issue | 10
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Start Page | 1057
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End Page | 1062
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Published Date | 1992-10
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
Oral Sciences
Medical Sciences
Institute of Advanced Medical Sciences
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