ID | 115628 |
Title Alternative | 腸炎ビブリオは炎症を誘導し、Cystic Fibrosis Transmembrane Conductance Regulatorを介して下痢を誘導する
CFTR associated diarrhea in VP-infection
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Author |
Iba, Hitomi
Tokushima University|Nagasaki International University
Shimohata, Takaaki
Tokushima University
Tokushima University Educator and Researcher Directory
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Kido, Junko
Tokushima University
Hatayama, Sho
Tokushima University
Uebanso, Takashi
Tokushima University
Tokushima University Educator and Researcher Directory
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Keywords | Vibrio parahaemolyticus
CFTR
inflammation
diarrhea
COX-2
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Content Type |
Thesis or Dissertation
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Description | Vibrio parahaemolyticus is a foodborne bacterium that causes acute gastroenteritis through the consumption of contaminated, raw, or undercooked seafood. Cystic fibrosis transmembrane conductance regulator (CFTR) is a well-characterized chloride channel that regulates several other ion channels and transporters to maintain water homeostasis in the gut lumen. Also, CFTR is a main target of bacterial infection-associated diarrhea. Hence, the aim of this study was to clarify the contribution of CFTR in V. parahaemolyticus-induced diarrhea in a mouse model of intestinal loop fluid accumulation, with CFTR inhibitors and a CFTR knockout model. The results indicated that CFTR plays a critical role in fluid accumulation in response to V. parahaemolyticus infection. We also investigated the inflammatory association in CFTR-mediated V. parahaemolyticus-induced fluid secretion with cyclooxygenase inhibitors and found that fluid accumulation was decreased by inhibition of cyclooxygenase 2 produced by neutrophils. These findings suggest that V. parahaemolyticus-inducing infiltration and activation of neutrophils also participated in CFTR mediated fluid secretion. This study reveals an important relationship between V. parahaemolyticus-induced diarrhea and inflammation in a mouse model.
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Journal Title |
The Journal of Medical Investigation
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ISSN | 13496867
13431420
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NCID | AA11166929
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Publisher | Tokushima University Faculty of Medicine
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Volume | 68
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Issue | 1-2
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Start Page | 59
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End Page | 70
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Sort Key | 59
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Published Date | 2021-02
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Remark | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Hitomi Ibaの学位論文として提出され,学位審査・授与の対象となっている。 |
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第3471号
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Diploma Number | 甲栄第282号
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Granted Date | 2021-01-28
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Degree Name |
Doctor of Nutritional Science
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Grantor |
Tokushima University
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departments |
Medical Sciences
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