| ID | 114712 |
| Title Alternative | ヒト歯髄幹細胞由来培養上清による皮膚の放射線障害の抑制効果
Dental pulp stem cell factors for treating RISR
|
| Author |
Kawarabayashi, Keita
Tokushima University
Hashimoto, Noboru
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Hibi, Hideharu
Nagoya University
|
| Keywords | human dental pulp stem cells
conditioned media
mesenchymal stem cells
radiation-induced skin reaction
cutaneous radiation syndrome
radiation-induced skin reactions
|
| Content Type |
Thesis or Dissertation
|
| Description | Radiation-induced skin ulceration is a frequent complication of radiotherapy for cancer treatment. Stem cells from human exfoliated deciduous teeth (SHEDs) can regenerate various tissues. In this study, we investigated the impact of SHED-conditioned media (SHED-CM) on radiation-induced ulceration. Mouse necks were locally irradiated with a single dose of 15 Gy of radiation. A week after the irradiation, most of the wild-type mice generated ulcer surrounded by severe erythema. Intra-venous administration of SHED-CM effectively inhibited the ulcer formation. Histological examination revealed that SHED-CM treatment inhibited radiation-induced dermal thickness and epithelial hyperplasia. SHED-CM could be a useful treatment option for radiation-induced skin ulceration.
|
| Journal Title |
Journal of Oral Health and Biosciences
|
| ISSN | 21896682
|
| Publisher | Shikoku Society of Dental Research
|
| Volume | 33
|
| Issue | 1
|
| Start Page | 1
|
| End Page | 7
|
| Sort Key | 1
|
| Published Date | 2020-06-12
|
| Remark | 内容要旨・審査要旨・論文本文の公開
本論文は，著者Keita Kawarabayashiの学位論文として提出され，学位審査・授与の対象となっている。 |
| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
|
| TextVersion |
ETD
|
| MEXT report number | 甲第3382号
|
| Diploma Number | 甲口第461号
|
| Granted Date | 2020-03-23
|
| Degree Name |
Doctor of Dental Science
|
| Grantor |
Tokushima University
|
| departments |
Oral Sciences
|
