ID | 115932 |
Title Alternative | 血液がん患者の好中球減少に伴う発熱の危険因子としての口腔細菌および口腔免疫との関連
Risk factors for chemotherapy-induced fever with neutropenia
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Author |
Sogawa, Yuka
Tokushima University|Tokushima Bunri University
Fukui, Makoto
Tokushima University
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Nakamura, Shingen
Tokushima University
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Abe, Masahiro
Tokushima University
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Keywords | Fever with neutropenia
Hematological cancer
Risk factor
Secretory immunoglobulin A
Fusobacterium nucleatum
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Content Type |
Thesis or Dissertation
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Description | The aim of this study is to investigate the association between chemotherapy-induced fever with neutropenia less than 1,500/μL (FwN) and oral bacteria and/or oral immunity in patients with hematological cancer. Thirty-two patients with hematological cancer were enrolled in the study. Secretory immunoglobulin A (sIgA) in saliva and the anaerobic bacteria in tongue coating of each subject was assessed before the first chemotherapy. Eleven subjects had an onset of FwN and 21 subjects did not during the observation periods. It was revealed by the cox-proportional hazard model analysis that the levels of sIgA were low (HR 0.98, p<0.05) and the rate of Fusobacterium nucleatum [F. nucleatum count per total bacterial count (%)] was high (HR 1.65, p<0.05) in patients with FwN onset. Using ROC curve analysis, the optimal cut-off point based on the AUC in the F. nucleatum / sIgA ratio was 0.023, and this model had a 78.4% probability (p<0.01). The risk of FwN onset was also significantly higher among the group of ≥ 0.023 F. nucleatum / sIgA ratio (HR 66.06, p<0.01). These results suggest that the rate of F. nucleatum and the levels of sIgA at baseline might be related to FwN onset as risk factors.
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Journal Title |
International Journal of Hematology
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ISSN | 09255710
18653774
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NCID | AA10797094
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Publisher | Japanese Society of Hematology|Springer Nature
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Volume | 112
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Issue | 6
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Start Page | 851
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End Page | 859
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Published Date | 2020-09-03
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Remark | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Yuka Sogawaの学位論文として提出され,学位審査・授与の対象となっている。 著者の申請により要約(2021-04-27公開)に替えて論文全文を公開(2022-12-16) |
Rights | © Japanese Society of Hematology 2020
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use (https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s12185-020-02975-x |
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第3472号
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Diploma Number | 甲口保第5号
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Granted Date | 2021-02-08
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Degree Name |
Doctor of Oral Health Science
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Grantor |
Tokushima University
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departments |
Oral Sciences
Medical Sciences
University Hospital
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