| ID | 113579 |
| Title Alternative | Selective Effects of Emi1 Depletion in Cancer
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| Author |
Shimizu, Natsumi
Hiroshima University|Kinki University
Izumi Nakajima, Nakako
National Institute of Radiological Sciences
Tsunematsu, Takaaki
Hiroshima University
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Ogawa, Ikuko
Hiroshima University
Kawai, Hidehiko
Hiroshima University
Hirayama, Ryoichi
National Institute of Radiological Sciences
Fujimori, Akira
National Institute of Radiological Sciences
Okayasu, Ryuichi
National Institute of Radiological Sciences
Ishimaru, Naozumi
The University of Tokushima
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Takata, Takashi
Hiroshima University
Kudo, Yasusei
Hiroshima University|The University of Tokushima
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| Content Type |
Journal Article
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| Description | Background: To improve the effectiveness of chemo- and radiotherapy only in cancer tissue is important for avoiding side effects.
Results: Emi1 depletion enhanced the sensitivity of anticancer reagents and X-ray irradiation in cancer cells. Conclusion: Emi1 siRNA would be a useful new modality for enhancing the effect of chemo- and radiotherapy in various tumors. Significance: This work provides new insights regarding synergistic effect of Emi1 knockdown in combination therapies. |
| Journal Title |
Journal of Biological Chemistry
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| ISSN | 1083351X
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| NCID | AA1202441X
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| Publisher | The American Society for Biochemistry and Molecular Biology
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| Volume | 288
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| Issue | 24
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| Start Page | 17238
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| End Page | 17252
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| Published Date | 2013-05-03
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| Remark | This research was originally published in the Journal of Biological Chemistry. Natsumi Shimizu, Nakako Izumi Nakajima, Takaaki Tsunematsu, Ikuko Ogawa, Hidehiko Kawai, Ryoichi Hirayama, Akira Fujimori, Akiko Yamada, Ryuichi Okayasu, Naozumi Ishimaru, Takashi Takata and Yasusei Kudo. Selective Enhancing Effect of Early Mitotic Inhibitor 1 (Emi1) Depletion on the Sensitivity of Doxorubicin or X-ray Treatment in Human Cancer Cells. J. Biol. Chem. 2013; Vol:288(24) pp.17238-17252.
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| Rights | © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
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| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
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| language |
eng
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| TextVersion |
Publisher
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| departments |
Medical Sciences
Oral Sciences
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