| ID | 113939 |
| Author |
Sano, Shigeki
Tokushima University
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Kujime, Eiko
Tokushima University|Matsuyama University
Tanaka, Hiroko
Tokushima University
Kitaike, Syuji
Tokushima University
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|
| Keywords | Stereogenic phosphorus atom
Methyl bis(2,2,2-trifluoroethyl)phosphonoacetate
Horner-Wadsworth-Emmons reagent
Kinetic resolution
Enzymatic hydrolysis
|
| Content Type |
Journal Article
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| Description | In this data article, we describe the enzymatic kinetic resolution of a series of racemic mixed phosphonoacetates, which were successfully prepared from methyl bis(2,2,2-trifluoroethyl)phosphonoacetate (Still-Gennari reagent) by alcoholysis with σ-symmetrical secondary alcohols in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). Porcine liver esterase (PLE)-catalyzed kinetic resolution of some of these racemic mixed phosphonoacetates proceeded in a highly stereoselective manner to furnish the chiral P-stereogenic phosphonoacetates (up to >99% ee).
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| Journal Title |
Chemical Data Collections
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| ISSN | 24058300
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| Publisher | Elsevier
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| Volume | 5-6
|
| Start Page | 12
|
| End Page | 20
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| Published Date | 2016-09-16
|
| Rights | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
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| TextVersion |
Author
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| departments |
Pharmaceutical Sciences
Technical Support Department
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