ID | 111388 |
Author |
Niimura, Takahiro
Tokushima University
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Imai, Toru
Nihon University
Ito, Tsuyoshi
Okayama University
Sagara, Hidenori
Matsuyama University
Hichiya, Hiroyuki
Godai Pharmacy
Esumi, Satoru
Okayama University
Takechi, Kenshi
Tokushima University
Koyama, Toshihiro
Okayama University
Amano, Manabu
Hyogo University of Health Sciences
Kurata, Naomi
Showa University
Kitamura, Yoshihisa
Okayama University
Nakura, Hironori
Okayama University
Sendo, Toshiaki
Okayama University
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Keywords | Emergency and critical care medical center
Kampo product
simple suspension method
tube administration
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Content Type |
Journal Article
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Description | In emergency and critical care medical centers, tube administration is employed for patients who have difficulty swallowing oral drugs owing to decreased consciousness or mechanical ventilation. However, tube clogging due to drug injection is a concern. We compared the crushing method with the simple suspension method for the passage of amlodipine, an antihypertensive drug, in combination with rikkunshito, which has been used to treat upper gastrointestinal disorders such as functional dyspepsia and gastroesophageal reflux in emergency and critical care medical centers, to ascertain the effect of Kampo products on the passage of other drugs during tube administration. When the crushing method was employed, poorly water-soluble solid products were formed, while a uniformly dispersed suspension was obtained using the simple suspension method. In addition, the passage rate of amlodipine through the tube was 64% and 93% in the crushing and simple suspension methods, respectively, thereby indicating that the simple suspension method provided more favorable than the crushing method. The results of this study suggested that the passage rate of amlodipine for patients who received Kampo products concurrently was higher when the simple suspension method was used, and an appropriate drug amount might well be able to administered to patients using this method.
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Journal Title |
The Journal of Medical Investigation
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ISSN | 13496867
13431420
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NCID | AA11166929
AA12022913
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Publisher | Faculty of Medicine Tokushima University
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Volume | 65
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Issue | 1-2
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Start Page | 32
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End Page | 36
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Sort Key | 32
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Published Date | 2018-02
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
Medical Sciences
University Hospital
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