ID | 115708 |
Author |
Iwasa, Takeshi
Tokushima University
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Yanagihara, Rie
Tokushima University
Komasaka, Mizuki
Tokushima University
Yano, Kiyohito
Tokushima University|Shikoku-Central Hospital
Mayila, Yiliyasi
Tokushima University
Tachibana, Ayaka
Tokushima University
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Keywords | low dose FSH
ovarian stimulation
ovulation induction
polycystic ovary syndrome
WHO group II
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Content Type |
Journal Article
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Description | Purpose: To evaluate the optimized protocol of low dose follicle‐stimulating hormone (FSH) therapy that has a starting dose of 50 IU/62.5 IU with a small increment dose (12.5 IU) for women with World Health Organization (WHO) II ovulatory disorder and unexplained infertility.
Methods: Anovulatory women with WHO group II ovulatory disorder (ovulation induction [OI] patients, n = 29), and with an unexplained infertility (ovarian stimulation [OS] patients, n = 21) were enrolled. The protocol of low dose step‐up FSH therapy was optimized for the starting dose as 50 IU (body mass index [BMI] < 20 group) and 62.5 IU (BMI ≥ 20 group) with the increment dose of 12.5 IU. Study outcomes were ovulation, monofollicular development and other variables. Results: In the OIpatients, the ovulation rate was 100% (BMI < 20 group) and 90.9% (BMI ≥ 20 group). Monofollicular development was 80.0% (BMI < 20) and 77.3% (BMI ≥ 20). The pregnancy rate was 60% (3/5 BMI < 20) and 18.2% (4/22 BMI ≥ 20). There was no multiple pregnancy. In the OSpatients, the ovulation rate was 100%. Monofollicular development was 85.7% (BMI < 20) and 76.6% (BMI ≥ 20). No pregnancy was achieved in the OSpatients. Conclusion: Optimized protocol of low dose FSH therapy setting a starting dose 50 IU/62.5 IU by BMI with an increment dose of 12.5 IU was safe and highly effective in WHO group II anovulatory patients. However, this protocol seemed uneffective for patients with unexplained infertility. |
Journal Title |
Reproductive Medicine and Biology
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ISSN | 14470578
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NCID | AA11706516
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Publisher | Japan Society for Reproductive Medicine|John Wiley & Sons
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Volume | 17
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Issue | 3
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Start Page | 315
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End Page | 324
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Published Date | 2018-06-12
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Rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License(https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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language |
eng
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departments |
Medical Sciences
University Hospital
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