ID | 110034 |
Title Alternative | Secreted Frizzled-Related Protein-1発現低下は肝内胆管癌において予後不良と関係している
|
Author |
Davaadorj, Mandakhnaran
Tokushima University
Saito, Yu
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Morine, Yuji
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Ikemoto, Tetsuya
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Takasu, Chie
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Yamada, Shinichiro
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Teraoku, Hiroki
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
|
Keywords | Intrahepatic cholangiocarcinoma
Prognostic factor
SFRP1
β-Catenin
|
Content Type |
Thesis or Dissertation
|
Description | Aims: Secreted Frizzled-Related Protein-1 (SFRP1) is a well-known negative regulator of the wingless type (Wnt)-β-catenin pathway and its inactivation plays an important role in the development and progression of many cancers. In this study, we aimed to determine the clinical significance of SFRP1 expression in intrahepatic cholangiocarcinoma (IHCC) and to define the relationship to Wnt-β-catenin pathway.
Methods: Fifty IHCC patients who had liver resection were enrolled in this study. SFRP1 protein expression was examined by immunohistochemistry in tumor tissues. The patients were divided into two groups: SFRP1 positive (n=30) and negative (n=20). Clinicopathological characteristics were analyzed. Results: SFRP1 significantly correlated with curability (Cur A, B vs. C, p=0.029); and recurrent pattern (intrahepatic vs. extrahepatic, p=0.010). The negative SFRP1 group had significantly poorer prognosis, and 5-year survival rates were 8.1% of the negative SFRP1 group and 44.6% of the positive SFRP1 group, respectively. Moreover, the disease-free survival rate in the negative SFRP1 group was significantly poorer ( p < 0.001). Multivariate analysis revealed that loss of SFRP1served as an independent prognostic factor in IHCC for both overall (HR, 2.923; 95% CI, 1.30-6.56; p=0.009) and disease-free (HR, 2.631; 95% CI, 1.31-5.27; p=0.006) survival. In addition, SFRP1 expression negatively correlated to β-catenin expression ( p=0.005). Conclusions: Those results suggested that the loss of SFRP1 could be a poor prognostic factor for IHCC, through the Wnt-β-catenin pathway. |
Journal Title |
European Journal of Surgical Oncology
|
ISSN | 07487983
|
NCID | AA10516435
|
Publisher | Elsevier
|
Volume | 43
|
Issue | 2
|
Start Page | 344
|
End Page | 350
|
Published Date | 2016-12-24
|
Remark | 内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨:LID201704121001.pdf 論文本文:LID201704121002.pdf 本論文は, 著者M. Davaadorjの学位論文として提出され, 学位審査・授与の対象となっている。 |
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
|
TextVersion |
ETD
|
MEXT report number | 甲第3008号
|
Diploma Number | 甲医第1312号
|
Granted Date | 2017-03-23
|
Degree Name |
Doctor of Medical Science
|
Grantor |
Tokushima University
|
departments |
Medical Sciences
University Hospital
|