ID | 117394 |
Author |
Nishi, Masaaki
Tokushima University
Tokushima University Educator and Researcher Directory
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Shimada, Mitsuo
Tokushima University
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Tokunaga, Takuya
Tokushima University
Tokushima University Educator and Researcher Directory
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Kashihara, Hideya
Tokushima University
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Takasu, Chie
Tokushima University
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Wada, Yuma
Tokushima University
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Eto, Shohei
Tokushima University
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Keywords | Rectal cancer
Chemoradiotherapy
Lymphocyte-CRP ratio
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Content Type |
Journal Article
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Description | Backgrounds: The lymphocyte to C-reactive protein (CRP) ratio (LCR) is an indicator of systemic inflammation and host–tumor cell interactions. The aim of this study was to investigate the prognostic significance of LCR in lower rectal cancer patients who received preoperative chemo-radiotherapy (CRT).
Methods: Forty-eight patients with lower rectal cancer who underwent CRT followed by curative surgery were enrolled in this study. Routine blood examinations were performed before and after CRT were used to calculate pre-CRT LCR and post-CRT LCR. The median LCR was used to stratify patients into low and high LCR groups for analysis. The correlation between pre- and post-CRT LCR and clinical outcomes was retrospectively investigated. Results: The pre-CRT LCR was significantly higher than the post-CRT LCR (11,765 and 6780, respectively, P < 0.05). The 5-year overall survival rate was significantly higher for patients with high post-CRT LCR compared with low post-CRT LCR (90.6% and 65.5%, respectively, P < 0.05). In univariate analysis, post-CRT LCR, post-CRT neutrophil to lymphocyte ratio, and fStage were significant prognostic factors for overall survival. In multivariate analysis, post-CRT LCR, but not other clinicopathological factors or prognostic indexes, was a significant prognostic factor for overall survival (P < 0.05). Conclusions: Post-CRT LCR could be a prognostic biomarker for patients with lower rectal cancer. |
Journal Title |
World Journal of Surgical Oncology
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ISSN | 14777819
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Publisher | BioMed Central|Springer Nature
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Volume | 19
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Start Page | 201
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Published Date | 2021-07-06
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Remark | 著者英表記誤記あり (誤)Mistuo Shimada →(正)Mitsuo Shimada
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Rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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DOI (Published Version) | |
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language |
eng
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Publisher
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departments |
Medical Sciences
University Hospital
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