ID | 111416 |
Author |
Sakai, Toshinori
Tokushima University
Tokushima University Educator and Researcher Directory
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Terai, Tomoya
Tokushima University
Goel, Vijay K.
University of Toledo
Biyani, Ashok
University of Toledo
Ebraheim, Nabil
University of Toledo
Hayashi, Fumio
Tokushima University
Morimoto, Masatoshi
Tokushima University
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Sairyo, Koichi
Tokushima University
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Keywords | Ligamentum flavum
Epiligament
Lumbar spinal canal stenosis
Collagenous fiber
Fibrosis
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Content Type |
Journal Article
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Description | Ligamentum flavum (LF) hypertrophy is one of the main factors of lumbar spinal canal stenosis (LSCS). The primary object of this study is to clarify the existence of epiligament in the LF and its role in hypertrophy, and to develop an LF hypertrophy animal model. A cadaveric spine from a 30-year-old man was used to investigate the existence of epiligament in LF. Five LF samples from LSCS patients were obtained to evaluate hypertrophied LF. To create a rat model, we destabilized the lumbar spine. Each LF was sagittally cut for histological evaluation. The epiligament was clearly evident in normal LF specimens, which stained pink on Elastica van Gieson and green on Masson Trichrome. Onelayer was observed on the dural side and another on the dorsal side of the LF. LSCS patients had an enlarged dorsal epiligament, at around 30 times that of the regular thin epiligament on the dural side. The destabilized rat model showed an enlarged dorsal epiligament, with a mean thickness 8-fold that of the control. LF hypertrophy may be due to enlargement of the dorsal epiligament. Mechanical loading of the LF is an important factor for inducing hypertrophy in the rat model.
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Journal Title |
The Journal of Medical Investigation
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ISSN | 13496867
13431420
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NCID | AA11166929
AA12022913
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Publisher | Faculty of Medicine Tokushima University
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Volume | 65
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Issue | 1-2
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Start Page | 85
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End Page | 89
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Sort Key | 85
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Published Date | 2018-02
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
University Hospital
Medical Sciences
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