| ID | 109903 |
| Title Transcription | Trastuzumab タンザイ リョウホウ ガ チョコウ シタ セツジョ フノウ シンコウ イガン ノ 1レイ
|
| Title Alternative | A case of a positive response to trastuzumab in a patient with HER２-overexpressing metastatic gastric cancer
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| Author |
Miyauchi, Masahiro
The Post-graduate Education Center, Tokushima University Hospital
Teramae, Satoshi
Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Miyamoto, Hiroshi
Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
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Otsuka, Kanako
Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Miyoshi, Jinsei
Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Kagawa, Miwako
Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Takaba, Azusa
Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Taniguchi, Tatsuya
Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
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Goji, Takahiro
Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
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Kitamura, Shinji
Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
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Takaoka, Tohshi
Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Niki, Miyako
Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Sato, Momoko
Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Muguruma, Naoki
Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
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Okahisa, Toshiya
Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
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Imoto, Issei
Department of Human Genetics and Public Health, the University of Tokushima Graduate School
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Sawa, Yasuhiko
Sawa Clinic
Takayama, Tetsuji
Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
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|
| Keywords | Trastuzumab
HER２
gastric cancer
docetaxel
S‐１
|
| Content Type |
Journal Article
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| Description | Trastuzumab, a humanized monoclonal antibody directed against human epidermal growth factor receptor２ （HER２）, has been shown to be active against metastatic gastric cancer that overexpress HER２. A ７８-year-old man presented with an edema in the lower legs. He was diagnosed as having advanced gastric cancers with multiple liver metastases in our hospital. Immunohistochemistry of the tumor cells revealed HER２ overexpression with an intensity of ３＋. The patient was treated with DS-T chemotherapy （Docetaxel＋S‐１＋Trastuzumab） because of the presence of renal dysfunction. Due to the adverse effect appeared with his skin, DS-T chemotherapy has been canceled and trastuzumab chemotherapy was continued. After １１ months of trastuzumab monotherapy, metastatic liver tumors were diminished. There is very few report of a positive response to trastuzumab in a patient with HER２‐overexpressing metastatic gastric cancer.
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| Journal Title |
四国医学雑誌
|
| ISSN | 00373699
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| NCID | AN00102041
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| Publisher | 徳島医学会
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| Volume | 70
|
| Issue | 5-6
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| Start Page | 185
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| End Page | 190
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| Sort Key | 185
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| Published Date | 2014-12-25
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| FullText File | |
| language |
jpn
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| TextVersion |
Publisher
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| departments |
University Hospital
Medical Sciences
|
