| ID | 118012 |
| Author |
Yagi, Mai
Tokushima University|Tokushima Prefectural Central Hospital
Muraki, Sho
Tokushima University|Shikoku Medical Center for Children and Adults
Matsuura, Tomomi
Tokushima University
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Bando, Yoshimi
Tokushima University
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Fujimoto, Shota
Tokushima University
Okamoto, Koichi
Tokushima University
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Muguruma, Naoki
Tokushima University
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Sata, Masataka
Tokushima University
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|
| Keywords | gastric cancer
pulmonary tumor thrombotic microangiopathy (PTTM)
cardiac catheterization
vascular endothelial growth factor (VEGF)
|
| Content Type |
Journal Article
|
| Description | A 66-year-old Japanese man receiving systemic chemotherapy for advanced gastric cancer presented with exertional dyspnea. D-dimer was elevated in the blood. Echocardiography revealed pulmonary hypertension, and a ventilation-perfusion scan indicated decreased perfusion in the bilateral lungs. Cardiac catheterization showed no evidence of pulmonary artery embolization and revealed cytologically confirmed adenocarcinoma. Thus, pulmonary tumor thrombotic microangiopathy (PTTM) was diagnosed. The patient died of respiratory failure on the 17th hospitalization day despite systemic chemotherapy. Retrospective serological testing revealed increased vascular endothelial growth factor in the pulmonary artery blood. This is a rare case with antemortem cytologically proven PTTM mediated by VEGF.
|
| Journal Title |
Internal Medicine
|
| ISSN | 13497235
|
| Publisher | The Japanese Society of Internal Medicine
|
| Volume | 61
|
| Issue | 10
|
| Start Page | 1491
|
| End Page | 1495
|
| Published Date | 2022-05-15
|
| Rights | The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
|
| TextVersion |
Publisher
|
| departments |
University Hospital
Medical Sciences
|
