ID | 110849 |
Author |
Sakaki, Manabu
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Oka, Natsuo
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Nakanishi, Ryoichi
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Yamaguchi, Kunihisa
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Fukumori, Tomoharu
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
KAKEN Search Researchers
Kanayama, Hiro-omi
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
|
Keywords | galectin-3
serum
bladder cancer
|
Content Type |
Journal Article
|
Description | We examine serum level of galectin-3 in patients with bladder cancer. We used serum samples of 67 patients with urological diseases and classified these patients into bladder cancer group (n=43) and control group (n=24). Galectin-3 concentration was measured by ELISA (Human Galectin-3 Assay Kit, IBL). And we selected the patient with high serum galectin-3 concentration (Urothelial Carcinoma, G3, pT3a pN0M0), we performed immunohistochemical staining with the VECTASTAIN ABC (Avidin Biotinylated enzyme Complex) system. Median value of serum galectin-3 concentration was 1068 pg/ml (range 551-2028) in the cancer group vs 584 pg/ml (range 259-1262) in controls. Serum galectin-3 concentration of the bladder cancer patients was statistically higher than that of controls (p<0.0005). There was no apparent correlation in serum galectin-3 concentration with the clinico-pathological features such as stage and grade. Higher expression of galectin-3 was observed in bladder cancer tissue than in normal bladder tissue. We suggest the measurement of serum galectin-3 is useful for diagnosis of bladder cancer.
|
Journal Title |
The journal of medical investigation : JMI
|
ISSN | 13431420
|
NCID | AA11166929
|
Volume | 55
|
Issue | 1-2
|
Start Page | 127
|
End Page | 132
|
Sort Key | 127
|
Published Date | 2008-02
|
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
|
TextVersion |
Publisher
|
departments |
Medical Sciences
University Hospital
|