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ID 117208
Author
Komine, Shoichi Teikyo Heisei University|University of Tsukuba
Miyazaki, Teruo Tokyo Medical University
Ishikura, Keisuke Josai University
Matsui, Takashi University of Tsukuba
Miyoshi, Takashi Tamagawa Academy
Honda, Akira Tokyo Medical University
Soya, Hideaki University of Tsukuba
Miyakawa, Shumpei University of Tsukuba
Ohmori, Hajime University of Tsukuba
Keywords
Taurine
Endurance exercise
Lipolysis
Fatty acid oxidation
Gluconeogenesis
Blood glucose concentration
Jugular vein cannulation
Content Type
Journal Article
Description
Taurine enhances physical performance; however, the underlying mechanism remains unclear. This study examined the effect of taurine on the overtime dynamics of blood glucose concentration (BGC) during endurance exercise in rats. Male F344 rats were subjected to transient treadmill exercise until exhaustion following 3 weeks of taurine supplementation or non-supplementation (TAU and CON groups). Every 10 min during exercise, BGC was measured in blood collected through cannulation of the jugular vein. Gluconeogenesis-, lipolysis-, and fatty acid oxidation-related factors in the plasma, liver, and skeletal muscles were also analyzed after 120-min run. Exercise time to exhaustion was significantly longer with taurine supplementation. BGC in the two groups significantly increased by 40 min and gradually and significantly decreased toward the respective exhaustion point. The decline in BGC from the peak at 40 min was significantly slower in the TAU group. The time when the once-increased BGC regressed to the 0-time level was significantly and positively correlated with exercise time until exhaustion. At the 120-min point, where the difference in BGC between the two groups was most significant, plasma free fatty acid concentration and acetyl-carnitine and N-acetyltaurine concentrations in skeletal muscle were significantly higher in the TAU group, whereas glycogen and glucogenic amino acid concentrations and G6Pase activity in the liver were not different between the two groups. Taurine supplementation enhances endurance capacity by delaying the decrease in BGC toward exhaustion through increases of lipolysis in adipose tissues and fatty acid oxidation in skeletal muscles during endurance exercise.
Journal Title
Amino Acids
ISSN
09394451
14382199
NCID
AA10842224
Publisher
Springer Nature
Volume
54
Issue
2
Start Page
251
End Page
260
Published Date
2022-02-05
Rights
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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language
eng
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departments
Liberal Arts and Sciences