ID | 116140 |
Title Alternative | レジストリデータによるがん患者の静脈血栓塞栓症の急性期死亡率
Thromboembolism and Cancer
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Author |
Okushi, Yuichiro
Tokushima University
Kusunose, Kenya
Tokushima University
Tokushima University Educator and Researcher Directory
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Okayama, Yoshihiro
Tokushima University
Zheng, Robert
Tokushima University
Nakai, Michikazu
National Cerebral and Cardiovascular Center
Sumita, Yoko
National Cerebral and Cardiovascular Center
Ise, Takayuki
Tokushima University
Tokushima University Educator and Researcher Directory
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Yamaguchi, Koji
Tokushima University
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Yagi, Shusuke
Tokushima University
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Yamada, Hirotsugu
Tokushima University
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Soeki, Takeshi
Tokushima University
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Wakatsuki, Tetsuzo
Tokushima University
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Sata, Masataka
Tokushima University
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Keywords | cardio-oncology
mortality
venous thromboembolism
Big data
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Content Type |
Thesis or Dissertation
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Description | BACKGROUND: The prognosis of patients with cancer-venous thromboembolism (VTE) is not well known because of a lack of registry data. Moreover, there is also no knowledge on how specific types are related to prognosis. We sought to evaluate the clinical characteristics and outcomes of patients with cancer-associated VTE, compared with a matched cohort without cancer using real-world registry data of VTE.
METHODS AND RESULTS: This study was based on the Diagnosis Procedure Combination database in the JROAD-DPC (Japanese Registry of All Cardiac and Vascular Diseases and the Diagnosis Procedure Combination). Of 5 106 151 total patients included in JROAD-DPC, we identified 49 580 patients who were first hospitalized with VTE from April 2012 to March 2017. Propensity score was estimated with a logistic regression model, with cancer as the dependent variable and 18 clinically relevant covariates. After propensity matching, there were 25 148 patients with VTE with or without cancer. On propensity score-matched analysis with 25 148 patients with VTE, patients with cancer had higher total in-hospital mortality within 7 days (1.3% versus 1.1%, odds ratio [OR], 1.66; 95% CI, 1.31–2.11; P<0.0001), 14 days (2.5% versus 1.5%, OR, 2.07; 95% CI, 1.72–2.49; P<0.0001), and 30 days (4.8% versus 2.0%, OR, 2.85; 95% CI, 2.45–3.31; P<0.0001). On analysis for each type of cancer, in-hospital mortality in 11 types of cancer was significantly high, especially pancreas (OR, 12.96; 95% CI, 6.41–26.20), biliary tract (OR, 8.67; 95% CI, 3.00–25.03), and liver (OR, 7.31; 95% CI, 3.05–17.50). CONCLUSIONS: Patients with cancer had a higher in-hospital acute mortality for VTE than those without cancer, especially in pancreatic, biliary tract, and liver cancers. |
Journal Title |
Journal of the American Heart Association
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ISSN | 20479980
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Publisher | The American Heart Association
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Volume | 10
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Issue | 11
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Start Page | e019373
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Published Date | 2021-05-22
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Remark | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Yuichiro Okushiの学位論文として提出され,学位審査・授与の対象となっている。 |
Rights | © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第3531号
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Diploma Number | 甲医第1501号
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Granted Date | 2021-07-29
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Degree Name |
Doctor of Medical Science
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Grantor |
Tokushima University
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departments |
University Hospital
Medical Sciences
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