ID | 111066 |
Title Alternative | Regulation of Cell Cycle by Ubiquitin-mediated Proteolysis and Carcinogenesis Induced by Its Dysregulation
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Author |
Kudo, Yasusei
Tokushima University
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Keywords | 細胞周期
ユビキチン分解
プロテアソーム
癌
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Content Type |
Journal Article
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Description | In the process of carcinogenesis, abnormal regulation of cell cycle regulators is essential. Cell cycle is driven by the activity of Cyclin/Cyclin-dependent kinase (Cdk) complex. The activity of Cyclin/Cdk1 is regulated by the ubiquitin-proteasome pathway via controlling protein level of Cyclins. In addition to Cyclins, the protein level of various cell cycle regulators is strictly and precisely regulated by the ubiquitin-proteasome pathway. In particular, SCF (Skp1-Cullin-F-box) and anaphasepromoting complex/cyclosome (APC/C) ubiquitin ligase complex are involved in ubiquitylation of cell cycle regulators. It recently has been shown that overexpression of oncogenic cell cycle regulators and reduced expression of tumor suppressive cell cycle regulators are caused by abnormal regulation of ubiquitin-mediated proteolysis in cancer. In this review, we introduce abnormal regulation of cell cycle regulators in cancer.
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Journal Title |
Journal of Oral Health and Biosciences
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ISSN | 21896682
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Publisher | 四国歯学会
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Volume | 30
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Issue | 1
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Start Page | 33
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End Page | 39
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Sort Key | 33
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Published Date | 2017-06-30
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DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
jpn
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TextVersion |
Publisher
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departments |
Oral Sciences
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