ID 113967
Author
Yoshitomi, Tatsuki University of Tokushima
Ohkura, Kazuto Suzuka University of Medical Science
Keywords
Voltage-dependent anion channel (VDAC)
Mitochondria
Pseudogene
Synteny
Content Type
Journal Article
Description
Rodent and human genomes were screened to identify pseudogenes of the type 1 voltage-dependent anion channel (VDAC1) in mitochondria. In addition to the 16 pseudogenes of rat VDAC1 identified in our recent study, 15 and 13 sequences were identified as pseudogenes of VDAC1 in mouse and human genome, respectively; and 4, 2, and 1 sequences, showing lower similarities with the VDAC1 sequence, were identified as “possible pseudogene candidates” in rat, mouse, and human, respectively. No syntenic combination was observed between rodent and human pseudogenes, but 2 and 1 possible pseudogene candidates of VDAC1 of rat and mouse, respectively, were found to have syntenic counterparts in mouse and rat genome, respectively; and these syntenic counterparts were genuine VDAC1 pseudogenes. Therefore, syntenic combinations of pseudogenes of VDAC1 were useful not only for a better understanding of the phylogenetic divergence history of rodents but also for ascertaining possible pseudogene candidates as genuine pseudogenes.
Journal Title
Genomics
ISSN
08887543
NCID
AA10678346
AA11537587
Publisher
Elsevier
Volume
104
Issue
2
Start Page
128
End Page
133
Published Date
2014-05-22
Rights
Open Archive
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Institute of Advanced Medical Sciences