Total for the last 12 months
number of access : ?
number of downloads : ?
ID 119312
Title Alternative
sPLA2-IIE, a Hair Follicular sPLA2
Author
Yamamoto, Kei Tokyo Metropolitan Institute of Medical Science|Tokushima University|Japan Agency for Medical Research and Development Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Miki, Yoshimi Tokyo Metropolitan Institute of Medical Science
Sato, Hiroyasu Tokyo Metropolitan Institute of Medical Science
Nishito, Yasumasa Tokyo Metropolitan Institute of Medical Science
Gelb, Michael H. University of Washington
Taketomi, Yoshitaka Tokyo Metropolitan Institute of Medical Science
Murakami, Makoto Tokyo Metropolitan Institute of Medical Science|Japan Agency for Medical Research and Development
Content Type
Journal Article
Description
Recent studies using knock-out mice for various secreted phospholipase A2 (sPLA2) isoforms have revealed their non-redundant roles in diverse biological events. In the skin, group IIF sPLA2 (sPLA2-IIF), an “epidermal sPLA2” expressed in the suprabasal keratinocytes, plays a fundamental role in epidermal-hyperplasic diseases such as psoriasis and skin cancer. In this study, we found that group IIE sPLA2 (sPLA2-IIE) was expressed abundantly in hair follicles and to a lesser extent in basal epidermal keratinocytes in mouse skin. Mice lacking sPLA2-IIE exhibited skin abnormalities distinct from those in mice lacking sPLA2-IIF, with perturbation of hair follicle ultrastructure, modest changes in the steady-state expression of a subset of skin genes, and no changes in the features of psoriasis or contact dermatitis. Lipidomics analysis revealed that sPLA2-IIE and -IIF were coupled with distinct lipid pathways in the skin. Overall, two skin sPLA2s, hair follicular sPLA2-IIE and epidermal sPLA2-IIF, play non-redundant roles in distinct compartments of mouse skin, underscoring the functional diversity of multiple sPLA2s in the coordinated regulation of skin homeostasis and diseases.
Journal Title
Journal of Biological Chemistry
ISSN
00219258
1083351X
NCID
AA1202441X
Publisher
American Society for Biochemistry and Molecular Biology|Elsevier
Volume
291
Issue
30
Start Page
15602
End Page
15613
Published Date
2016-05-23
Rights
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Bioscience and Bioindustry