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ID 116055
Title Alternative
社会経済的地位と消化器がんの関係について : 症例対照研究
Author
Kawakatsu, Yukino Aichi Cancer Center|Tokushima University
Koyanagi, Yuriko N. Aichi Cancer Center
Oze, Isao Aichi Cancer Center
Kasugai, Yumiko Aichi Cancer Center
Yamaguchi, Rui Aichi Cancer Center|Nagoya University
Ito, Hidemi Aichi Cancer Center|Nagoya University
Matsuo, Keitaro Aichi Cancer Center|Nagoya University
Keywords
Socioeconomic status
digestive tract cancer
cancer risk
case-control study
areal deprivation index
Content Type
Thesis or Dissertation
Description
Although socioeconomic status (SES) has been associated with cancer risk, little research on this association has been done in Japan. To evaluate the association between SES and digestive tract cancer risk, we conducted a case-control study for head and neck, esophageal, stomach, and colorectal cancers in 3188 cases and the same number of age- and sex-matched controls within the framework of the Hospital-based Epidemiological Research Program at Aichi Cancer Center III (HERPACC III). We employed the education level and areal deprivation index (ADI) as SES indicators. The association was evaluated with odds ratios (ORs) and 95% confidence intervals (CIs) by conditional logistic models adjusted for potential confounders. Even after allowance for known cancer risk factors, the education level showed linear inverse associations with head and neck, stomach, and colorectal cancers. Compared to those educated to junior high school, those with higher education showed statistically significantly lower risks of cancer (0.43 (95% CI: 0.27–0.68) for head and neck, 0.52(0.38–0.69) for stomach, and 0.52(0.38–0.71) for colorectum). Consistent with these results for the educational level, the ADI in quintiles showed positive associations with head and neck, esophageal, and stomach cancers (p-trend: p = 0.035 for head and neck, p = 0.02 for esophagus, and p = 0.013 for stomach). Interestingly, the positive association between ADI and stomach cancer risk disappeared in the additional adjustment for Helicobacter pylori infection and/or atrophic gastritis status. In conclusion, a lower SES was associated with an increased risk of digestive cancers in Japan and should be considered in cancer prevention policies for the target population.
Description Alternative
An association between socioeconomic status (SES) and cancer risk has been reported, but little is known in Asia. We revealed an association between SES, including education level and areal deprivation index (ADI), and digestive tract cancers in Japan. Lower SES was associated with an increased risk of digestive cancers. For stomach cancer, the positive association with ADI disappeared following an additional adjustment of Helicobacter pylori infection and/or atrophic gastritis status. Cancer prevention policy should consider both individual and regional perspectives by the integration of SES in the target population.
Journal Title
Cancers
ISSN
20726694
Publisher
MDPI
Volume
12
Issue
11
Start Page
3258
Published Date
2020-11-04
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Yukino Kawakatsuの学位論文として提出され,学位審査・授与の対象となっている。
Rights
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3507号
Diploma Number
甲医第1496号
Granted Date
2021-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences