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ID 118320
Title Alternative
妊娠期前の母親における腸内細菌叢の喪失が以降の世代の腸内細菌叢、食物アレルギー発症、エピゲノム修飾に与える影響について
MATERNAL GUT MICROBIOTA AND FOOD ALLERGY IN OFFSPRING
Author
Aizawa, Shinta Tokushima University
Shimohata, Takaaki Fukui Prefectural University KAKEN Search Researchers
Keywords
Developmental Origins of Health and Disease
DNA methylation
gut microbiota
food allergy
antibiotics
Treg (Regulatory T cell)
Content Type
Thesis or Dissertation
Description
Maternal environments affect the health of offspring in later life. Changes in epigenetic modifications may partially explain this phenomenon. The gut microbiota is a critical environmental factor that influences epigenetic modifications of host immune cells and the development of food allergies. However, whether changes in the maternal gut microbiota affect the development of food allergies and related epigenetic modifications in subsequent generations remains unclear. Here, we investigated the effects of antibiotic treatment before pregnancy on the development of the gut microbiota, food allergies, and epigenetic modifications in F1 and F2 mice. We found that pre-conception antibiotic treatment affected the gut microbiota composition in F1 but not F2 offspring. F1 mice born to antibiotic-treated mothers had a lower proportion of butyric acid-producing bacteria and, consequently, a lower butyric acid concentration in their cecal contents. The methylation level in the DNA of intestinal lamina propria lymphocytes, food allergy susceptibility, and production of antigen-specific IgE in the F1 and F2 mice were not different between those born to control and antibiotic-treated mothers. In addition, F1 mice born to antibiotic-treated mothers showed increased fecal excretion related to the stress response in a novel environment. These results suggest that the maternal gut microbiota is effectively passed onto F1 offspring but has little effect on food allergy susceptibility or DNA methylation levels in offspring.
Journal Title
Bioscience of Microbiota, Food and Health
ISSN
21863342
Publisher
BMFH Press
Volume
42
Issue
3
Start Page
203
End Page
212
Published Date
2023
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Shinta Aizawaの学位論文として提出され,学位審査・授与の対象となっている。
Rights
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3736号
Diploma Number
甲栄第301号
Granted Date
2023-03-30
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
Medical Sciences