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ID 111158
Title Alternative
イソフルラン誘発性のポストコンディショニング効果はミトコンドリアのカルシウム依存性カリウムチャネルを介している
Isoflurane actions via the mKCa channel
Author
Kinoshita, Michiko Tokushima University
Fukuta, Kohei Tokushima University
Keywords
Mitochondrial calcium-activated potassium channel
Anesthetic-induced postconditioning
Isoflurane
Content Type
Thesis or Dissertation
Description
Purpose : Activation of the mitochondrial calcium-activated potassium (mKCa) channel reportedly confers resistance to myocardial ischemic stress. However, the role of the mKCa channel in postconditioning induced by volatile anesthetic remains unclear. Methods :Male Japanese white rabbits underwent coronary artery occlusion for 30 min followed by reperfusion for 3 h. Volatile anesthetic, isoflurane, was administered at 3min prior to reperfusion for 5 min. Rabbits were injected with the mKCa channel blocker, iberiotoxin, or the mKCa channel opener, NS1619, at 8 min prior to reperfusion. Myocardial infarct size and the area at risk (AAR) were measured at the end of the experiment. Results : Isoflurane significantly reduced infarct size (23.0±9.8% of the AAR, P<0.05) compared with the control (44.0±9.1%). Iberiotoxin abolished the cardioprotective impact of isoflurane (43.0±11.6%), while iberiotoxin alone exerted no effect on infarct size (45.0±9.5%). NS1619 and isoflurane/ NS1619 both significantly reduced infarct size (21.0±10.3% and 19.0±8.8%, respectively, P<0.05 vs control group), but isoflurane/NS1619 showed no additional benefits compared with isoflurane alone. Conclusion : These results indicate that activation of the mKCa channel contribute isoflurane-induced postconditioning.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
63
Issue
1-2
Start Page
80
End Page
84
Sort Key
80
Published Date
2016-02
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201606071002.pdf
論文本文 : LID201606071003.pdf
本論文は,著者Michiko Kinoshitaの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2948号
Diploma Number
甲医第1281号
Granted Date
2016-03-22
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital