Total for the last 12 months
number of access : ?
number of downloads : ?
ID 119318
Title Alternative
大脳皮質体性感覚野の口腔領域における局所回路オシレーションに対するGABAB受容体の作用 : NMDA受容体に焦点を当てて
Author
Kanayama, Hiroyuki Tokushima University|National Hospital Organization Osaka National Hospital
Tominaga, Takashi Tokushima Bunri University
Tominaga, Yoko Tokushima Bunri University
Kato, Nobuo Kanazawa Medical University
Keywords
Caffeine
GABAB receptor
NMDA receptor
Network oscillation
Oral somatosensory cortex
Voltage-sensitive dye
Content Type
Thesis or Dissertation
Description
The balance of activity between glutamatergic and GABAergic networks is particularly important for oscillatory neural activities in the brain. Here, we investigated the roles of GABAB receptors in network oscillation in the oral somatosensory cortex (OSC), focusing on NMDA receptors. Neural oscillation at the frequency of 8–10 Hz was elicited in rat brain slices after caffeine application. Oscillations comprised a non-NMDA receptor-dependent initial phase and a later NMDA receptor-dependent oscillatory phase, with the oscillator located in the upper layer of the OSC. Baclofen was applied to investigate the actions of GABAB receptors. The later NMDA receptor-dependent oscillatory phase completely disappeared, but the initial phase did not. These results suggest that GABAB receptors mainly act on NMDA receptor, in which metabotropic actions of GABAB receptors may contribute to the attenuation of NMDA receptor activities. A regulatory system for network oscillation involving GABAB receptors may be present in the OSC.
Journal Title
The Journal of Physiological Sciences
ISSN
18806546
18806562
NCID
AA12129145
Publisher
BioMed Central/Springer Nature
Volume
74
Start Page
16
Published Date
2024-03-12
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Hiroyuki Kanayamaの学位論文として提出され,学位審査・授与の対象となっている。
Rights
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3789号
Diploma Number
甲口第503号
Granted Date
2024-03-14
Degree Name
Doctor of Dental Science
Grantor
Tokushima University
departments
Oral Sciences