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ID 115573
Title Alternative
Association Between PSCA Variants and Duodenal Ulcer Risk
Author
Usui, Yoshiaki Aichi Cancer Center|Okayama University
Matsuo, Keitaro Aichi Cancer Center|Nagoya University
Oze, Isao Aichi Cancer Center
Ugai, Tomotaka Aichi Cancer Center
Koyanagi, Yuriko Aichi Cancer Center
Maeda, Yoshinobu Okayama University
Ito, Hidemi Aichi Cancer Center|Nagoya University
Hishida, Asahi Nagoya University
Takeuchi, Kenji Nagoya University
Tamura, Takashi Nagoya University
Tsukamoto, Mineko Nagoya University
Kadomatsu, Yuka Nagoya University
Hara, Megumi Saga University
Nishida, Yuichiro Saga University
Shimoshikiryo, Ippei Kagoshima University
Takezaki, Toshiro Kagoshima University
Ozaki, Etsuko Kyoto Prefectural University of Medicine
Matsui, Daisuke Kyoto Prefectural University of Medicine
Watanabe, Isao Kyoto Prefectural University of Medicine
Suzuki, Sadao Nagoya City University
Watanabe, Miki Nagoya City University
Nakagawa-Senda, Hiroko Nagoya City University
Mikami, Haruo Chiba Cancer Center
Nakamura, Yohko Chiba Cancer Center
Kuriki, Kiyonori University of Shizuoka
Takashima, Naoyuki Kindai University
Kadota, Aya Shiga University of Medical Science
Ikezaki, Hiroaki Kyushu University
Murata, Masayuki Kyushu University
Nakatochi, Masahiro Nagoya University
Momozawa, Yukihide RIKEN Center for Integrative Medical Sciences
Kubo, Michiaki RIKEN Center for Integrative Medical Sciences
Wakai, Kenji Nagoya University
Keywords
PSCA
duodenal ulcer
cross-sectional study
Japan
Content Type
Journal Article
Description
Background: While duodenal ulcer (DU) and gastric cancer (GC) are both H. pylori infection-related diseases, individuals with DU are known to have lower risk for GC. Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). Following these initial reports, however, few studies have since validated these associations. Here, we aimed to validate the association between variations in PSCA and the risk of DU/GU and evaluate its interaction with environmental factors in a Japanese population.
Methods: Six PSCA SNPs were genotyped in 584 DU cases, 925 GU cases, and 8,105 controls from the Japan Multi-Institutional Collaborative Cohort (J-MICC). Unconditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between the SNPs and risk of DU/GU.
Results: PSCA rs2294008 C-allele was associated with per allele OR of 1.34 (95% CI, 1.18–1.51; P = 2.28 × 10−6) for the risk of DU. This association was independent of age, sex, study site, smoking habit, drinking habit, and H. pylori status. On the other hand, we did not observe an association between the risk of GU and PSCA SNPs.
Conclusions: Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population.
Journal Title
Journal of Epidemiology
ISSN
13499092
09175040
NCID
AA10952696
Publisher
Japan Epidemiological Association
Volume
31
Issue
1
Start Page
12
End Page
20
Published Date
2021-01-05
Rights
This is an open access article distributed under the terms of Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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DOI (Published Version)
URL ( Publisher's Version )
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language
eng
TextVersion
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departments
Medical Sciences