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ID 116254
Tamura, Takashi Nagoya University
Kuriyama, Nagato Kyoto Prefectural University of Medicine
Koyama, Teruhide Kyoto Prefectural University of Medicine
Ozaki, Etsuko Kyoto Prefectural University of Medicine
Matsui, Daisuke Kyoto Prefectural University of Medicine
Kadomatsu, Yuka Nagoya University
Tsukamoto, Mineko Nagoya University
Kubo, Yoko Nagoya University
Okada, Rieko Nagoya University
Hishida, Asahi Nagoya University
Sasakabe, Tae Nagoya University|Aichi Medical University
Kawai, Sayo Nagoya University|Aichi Medical University
Naito, Mariko Nagoya University|Hiroshima University
Takashima, Naoyuki Shiga University of Medical Science|Kindai University
Kadota, Aya Shiga University of Medical Science
Tanaka, Keitaro Saga University
Hara, Megumi Saga University
Suzuki, Sadao Nagoya City University
Nakagawa‑Senda, Hiroko Nagoya City University
Takezaki, Toshiro Kagoshima University
Shimoshikiryo, Ippei Kagoshima University
Ikezaki, Hiroaki Kyushu University
Murata, Masayuki Kyushu University
Oze, Isao Aichi Cancer Center Research Institute
Ito, Hidemi Aichi Cancer Center Research Institute|Nagoya University
Mikami, Haruo Chiba Cancer Center Research Institute
Nakamura, Yohko Chiba Cancer Center Research Institute
Kuriki, Kiyonori University of Shizuoka
Uemura, Hirokazu Tokushima University|University of Hyogo KAKEN Search Researchers
Takeuchi, Kenji Nagoya University
Wakai, Kenji Nagoya University
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Journal Article
There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B12 as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B12, and dietary folate intake with the prevalence of hypertension. Participants included 1046 men and 1033 women (mean age ± standard deviation: 56.0 ± 8.9 years) in the Japan Multi-Institutional Collaborative Cohort Study. Dietary folate intake was estimated using a validated food frequency questionnaire. Hypertension was defined based on measured blood pressure and use of antihypertensive medication. A total of 734 participants (35.3%) had hypertension. Multivariate-adjusted odds ratios of hypertension for the highest quartile group of Hcy were 2.36 (95% CI 1.41–3.96) in men and 1.86 (95% CI 1.11–3.11) in women, as compared with the lowest group (P for trend = 0.014 and 0.005, respectively). Dietary folate intake was not correlated with hypertension in both men and women (P for trend = 0.099 and 0.703, respectively). Plasma vitamin B12 was positively associated with hypertension only in women (P for trend = 0.027). Plasma Hcy level was positively linked with hypertension after controlling for covariates, including folate and vitamin B12.
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Scientific Reports
Springer Nature
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Medical Sciences