Breastfeeding history and metabolic syndrome in parous women
Matsunaga, Takashi Nagoya University
Kadomatsu, Yuka Nagoya University
Tsukamoto, Mineko Nagoya University
Kubo, Yoko Nagoya University
Okada, Rieko Nagoya University
Nagayoshi, Mako Nagoya University
Tamura, Takashi Nagoya University
Hishida, Asahi Nagoya University
Takezaki, Toshiro Kagoshima University
Shimoshikiryo, Ippei Kagoshima University
Suzuki, Sadao Nagoya City University
Nakagawa, Hiroko Nagoya City University
Takashima, Naoyuki Shiga University of Medical Science|Kindai University
Saito, Yoshino Shiga University of Medical Science|Aino University
Kuriki, Kiyonori University of Shizuoka
Arisawa, Kokichi Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Katsuura-Kamano, Sakurako Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kuriyama, Nagato Kyoto Prefectural University of Medicine
Matsui, Daisuke Kyoto Prefectural University of Medicine
Mikami, Haruo Chiba Cancer Center Research Institute
Nakamura, Yohko Chiba Cancer Center Research Institute
Oze, Isao Aichi Cancer Center Research Institute
Ito, Hidemi Aichi Cancer Center Research Institute|Nagoya University
Murata, Masayuki Kyushu University
Ikezaki, Hiroaki Kyushu University
Nishida, Yuichiro Saga University
Shimanoe, Chisato Saga University
Takeuchi, Kenji Nagoya University
Wakai, Kenji Nagoya University
The aim of the present study was to investigate the associations between breastfeeding and the prevalence of metabolic syndrome in community-dwelling parous women and to clarify whether the associations depend on age.
The present cross-sectional study included 11,118 women, aged 35–69 years. Participants’ longest breastfeeding duration for one child and their number of breastfed children were assessed using a self-administered questionnaire, and their total breastfeeding duration was approximated as a product of the number of breastfed children and the longest breastfeeding duration. The longest and the total breastfeeding durations were categorized into none and tertiles above 0 months. Metabolic syndrome and cardiovascular risk factors (obesity, hypertension, dyslipidemia, and hyperglycemia) were defined as primary and secondary outcomes, respectively. Associations between breastfeeding history and metabolic syndrome or each cardiovascular risk factor were assessed using multivariable unconditional logistic regression analysis.
Among a total of 11,118 women, 10,432 (93.8%) had ever breastfed, and 1,236 (11.1%) had metabolic syndrome. In participants aged <55 years, an inverse dose–response relationship was found between the number of breastfed children and the prevalence of metabolic syndrome; multivariable-adjusted odds ratios for 1, 2, 3, and ≥4 breastfed children were 0.60 (95% confidence interval [CI]: 0.31 to 1.17), 0.50 (95% CI: 0.29 to 0.87), 0.44 (95% CI: 0.24 to 0.84), and 0.35 (95% CI: 0.14 to 0.89), respectively. The longest and total breastfeeding durations of longer than 0 months were also associated with lower odds of metabolic syndrome relative to no breastfeeding history in participants aged <55 years. In contrast, all measures of breastfeeding history were not significantly associated with metabolic syndrome and cardiovascular risk factors in participants aged ≥55 years old.
Breastfeeding history may be related to lower prevalence of metabolic syndrome in middle-aged parous women.
This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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