| ID | 117591 |
| Title Alternative | メタボリックシンドロームおよび代謝的に不健康な肥満とがん死亡率との関連 : 日本多施設共同コーホート（J-MICC）研究
Metabolic syndrome and metabolically unhealthy obesity with cancer mortality
|
| Author |
Nguyen, Tien Van
Tokushima University
Arisawa, Kokichi
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Katsuura-Kamano, Sakurako
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Nagayoshi, Mako
Nagoya University
Okada, Rieko
Nagoya University
Hishida, Asahi
Nagoya University
Tamura, Takashi
Nagoya University
Hara, Megumi
Saga University
Tanaka, Keitaro
Saga University
Nishimoto, Daisaku
Kagoshima University
Shibuya, Keiichi
Kagoshima University
Koyama, Teruhide
Kyoto Prefectural University of Medicine
Watanabe, Isao
Kyoto Prefectural University of Medicine
Suzuki, Sadao
Nagoya City University
Nishiyama, Takeshi
Nagoya City University
Kuriki, Kiyonori
University of Shizuoka
Nakamura, Yasuyuki
Shiga University of Medical Science
Saito, Yoshino
Aino University
Ikezaki, Hiroaki
Kyushu University
Otonari, Jun
Kyushu University
Koyanagi, Yuriko N.
Aichi Cancer Center Research Institute
Matsuo, Keitaro
Aichi Cancer Center Research Institute
Mikami, Haruo
Chiba Cancer Center Research Institute
Kusakabe, Miho
Chiba Cancer Center Research Institute
Takeuchi, Kenji
Nagoya University
Wakai, Kenji
Nagoya University
|
| Keywords | Cancer mortality
Cohort study
Metabolic syndrome
Metabolically unhealthy obesity
Japanese
|
| Content Type |
Thesis or Dissertation
|
| Description | Purpose
The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population. Methods We used data from the Japan Multi-Institutional Collaborative Cohort Study. The study population consisted of 28,554 eligible subjects (14,103 men and 14,451 women) aged 35–69 years. MetS was diagnosed based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the Japan Society for the Study of Obesity (JASSO), using the body mass index instead of waist circumference. The Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total cancer mortality in relation to MetS and its components. Additionally, the associations of obesity and the metabolic health status with cancer mortality were examined. Results During an average 6.9-year follow-up, there were 192 deaths from cancer. The presence of MetS was significantly correlated with increased total cancer mortality when the JASSO criteria were used (HR = 1.51, 95% CI 1.04–2.21), but not when the NCEP-ATP III criteria were used (HR = 1.09, 95% CI 0.78–1.53). Metabolic risk factors, elevated fasting blood glucose, and MUHO were positively associated with cancer mortality (P <0.05). Conclusion MetS diagnosed using the JASSO criteria and MUHO were associated with an increased risk of total cancer mortality in the Japanese population. |
| Journal Title |
PLOS ONE
|
| ISSN | 19326203
|
| Publisher | PLOS
|
| Volume | 17
|
| Issue | 7
|
| Start Page | e0269550
|
| Published Date | 2022-07-08
|
| Remark | 内容要旨・審査要旨・論文本文の公開
本論文は，著者Tien Van Nguyenの学位論文として提出され，学位審査・授与の対象となっている。 |
| Rights | This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
|
| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
|
| TextVersion |
ETD
|
| MEXT report number | 甲第3696号
|
| Diploma Number | 甲医第1565号
|
| Granted Date | 2023-03-23
|
| Degree Name |
Doctor of Medical Science
|
| Grantor |
Tokushima University
|
| departments |
Medical Sciences
|
