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ID 117191
Koga, Kayoko Saga University|Fukuoka University
Hara, Megumi Saga University
Shimanoe, Chisato Saga University
Nishida, Yuichiro Saga University
Furukawa, Takuma Saga University
Iwasaka, Chiharu Saga University
Tanaka, Keitaro Saga University
Otonari, Jun Kyushu University|International University of Health and Welfare
Ikezaki, Hiroaki Kyushu University
Kubo, Yoko Nagoya University
Kato, Yasufumi Nagoya University
Tamura, Takashi Nagoya University
Hishida, Asahi Nagoya University
Matsuo, Keitaro Aichi Cancer Center Research Institute|Nagoya University
Ito, Hidemi Aichi Cancer Center Research Institute|Nagoya University
Nakamura, Yohko Chiba Cancer Center Research Institute
Kusakabe, Miho Chiba Cancer Center Research Institute
Nishimoto, Daisaku Kagoshima University
Shibuya, Keiichi Kagoshima University
Suzuki, Sadao Nagoya City University
Watanabe, Miki Nagoya City University
Ozaki, Etsuko Kyoto Prefectural University of Medicine
Matsui, Daisuke Kyoto Prefectural University of Medicine
Kuriki, Kiyonori University of Shizuoka
Takashima, Naoyuki Kindai University|Shiga University of Medical Science
Kadota, Aya Shiga University of Medical Science
Takeuchi, Kenji Nagoya University
Wakai, Kenji Nagoya University
Content Type
Journal Article
Elucidating the risk factors for chronic kidney disease is important for preventing end-stage renal disease and reducing mortality. However, little is known about the roles of psychosocial stress and stress coping behaviors in deterioration of the renal function, as measured by the estimated glomerular filtration rate (eGFR). This cross-sectional study of middle-aged and older Japanese men (n = 31,703) and women (n = 38,939) investigated whether perceived stress and coping strategies (emotional expression, emotional support seeking, positive reappraisal, problem solving, and disengagement) were related to the eGFR, with mutual interactions. In multiple linear regression analyses adjusted for age, area, lifestyle factors, and psychosocial variables, we found a significant inverse association between perceived stress and the eGFR in men (Ptrend = 0.02), but not women. This male-specific inverse association was slightly attenuated after adjustment for the history of hypertension and diabetes and was more evident in lower levels of emotional expression (Pinteraction = 0.003). Unexpectedly, problem solving in men (Ptrend < 0.001) and positive reappraisal in women (Ptrend = 0.002) also showed an inverse association with the eGFR. Perceived stress may affect the eGFR, partly through the development of hypertension and diabetes. The unexpected findings regarding coping strategies require the clarification of the underlying mechanisms, including the hormonal and immunological aspects.
Journal Title
Scientific Reports
Springer Nature
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Medical Sciences