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ID 113577
Author
Iizuka, Shinji Sanford-Burnham Medical Research Institute
Keywords
matrix metalloproteinase
invasion
angiogenesis
head and neck squamous cell carcinoma
Content Type
Journal Article
Description
Extracellular matrix degradation by matrix metalloproteinases (MMPs) plays a pivotal role in cancer progression by promoting motility, invasion and angiogenesis. Studies have shown that MMP expression is increased in head and neck squamous cell carcinomas (HNSCCs), one of the most common cancers in the world, and contributes to poor outcome. In this review, we examine the expression pattern of MMPs in HNSCC by microarray datasets and summarize the current knowledge of MMPs, specifically MMP-1, -3, -7 -10, -12, -13, 14 and -19, that are highly expressed in HNSCCs and involved cancer invasion and angiogenesis.
Journal Title
Cancers
ISSN
20726694
Publisher
MDPI
Volume
6
Issue
1
Start Page
396
End Page
415
Published Date
2014-02-13
Rights
© 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences