| ID | 59702 |
| Title Transcription | イソプレン ソクサ オ ユウスル ショクブツ セイブン ノ ex vivo ユウキ ゴウセイ ト ソノ セイリ カッセイ ノ ヒョウカ
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| Title Alternative | Design, ex vivo Synthesis, and Biological Activities of Plant Constituents Containing an Isoprene Side-chain Based on Isoprenomics
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| Author |
Uto, Yoshihiro
Division of Bioinformatics Engineering, Department of Life System, Institute of Technology and Science, Graduate School of The University of Tokushima
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Koyama, Daisuke
Graduate School of Advanced Technology and Science, The University of Tokushima
Otomo, Naoki
Graduate School of Advanced Technology and Science, The University of Tokushima
Abe, Chiaki
Graduate School of Advanced Technology and Science, The University of Tokushima
Shirai, Tadashi
Graduate School of Advanced Technology and Science, The University of Tokushima
Nakata, Eiji
Division of Bioinformatics Engineering, Department of Life System, Institute of Technology and Science, Graduate School of The University of Tokushima
Hori, Hitoshi
Division of Bioinformatics Engineering, Department of Life System, Institute of Technology and Science, Graduate School of The University of Tokushima
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|
| Keywords | Antioxidant
Acyclic tocopherol
Antiatherosclerosis drug
phytyl quinol
Chick embryo chorioallantoic membrane
Isoprenomics
|
| Content Type |
Departmental Bulletin Paper
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| Description | Phytyl quinols, namely acyclic tocopherols, are key intermediates of tocopherol biosynthesis,
but their biological activities remain unclear. We therefore investigated the structure-activity relationship of phytyl quinols to apply a chemical biosynthesis design for an antiatherosclerosis drug based on isoprenomics. We have achieved the biosynthesis-oriented synthesis of α- and β-phytyl quinol as an unnatural intermediate, other γ- and δ-phytyl quinol as a natural one. All four phytyl quinols showed almost the same moderate inhibitory activity against low-density lipoprotein oxidation instead of their different degree of C-methylation with character different from tocopherols. In vivo toxicities of phytyl quinols against chick embryo chorioallantoic membrane vasculature were hardly observed. We proposed phytyl quinols were possible antioxidants in plants and animals, like vitamin E. |
| Journal Title |
徳島大学大学院ソシオテクノサイエンス研究部研究報告
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| ISSN | 21859094
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| NCID | AA12214889
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| Publisher | 徳島大学大学院ソシオテクノサイエンス研究部
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| Volume | 53
|
| Start Page | 52
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| End Page | 56
|
| Sort Key | 52
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| Published Date | 2008-05-30
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| EDB ID | |
| FullText File | |
| language |
jpn
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| departments |
Bioscience and Bioindustry
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