| ID | 110037 |
| Title Alternative | 腎発生におけるプロレニン、プロレニン受容体の役割検討
Soluble (pro)renin receptor in neonates
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| Author |
Terada, Tomomasa
Tokushima University
Urushihara, Maki
Tokushima University
Tokushima University Educator and Researcher Directory
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Saijo, Takahiko
Tokushima University
Nakagawa, Ryuji
Tokushima University
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Kagami, Shoji
Tokushima University
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|
| Keywords | Renin-angiotensin
Gestational age
Cord blood
Enzyme-linked immunosorbent assay
Immunohistochemistry
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| Content Type |
Thesis or Dissertation
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| Description | Although a recent study demonstrated that the (pro)renin receptor ((P)RR) was highly expressed in the developing kidney during the mouse embryonic development, the mechanism by which (P)RR supports renal development in humans is not fully understood. In this study, we examined the plasma levels of (pro)renin and soluble (P)RR (s(P)RR) in cord blood and neonates as well as (P)RR expression in human kidney tissues. Samples were collected from 57 preterm and 67 full-term human neonates. (Pro)renin and s(P)RR levels were measured using enzyme-linked immunosorbent assays. Additionally, we performed an immunohistochemical (IHC) analysis of kidney tissues from neonates and minor glomerular abnormalities in order to assess (P)RR expression in the kidney. Plasma (pro)renin and s(P)RR levels in cord blood were significantly higher in preterm neonates than in full-term neonates. Four weeks after birth, these differences were no longer evident for either plasma (pro)renin or s(P)RR levels between the two groups. Importantly, plasma (pro)renin and s(P)RR levels in cord blood were inversely correlated with gestational age. Furthermore, IHC indicated that renal expression levels of (P)RR in neonates was stronger than that in minor glomerular abnormalities.
Conclusion: (P)RR may play a pivotal role in prenatal renal development in humans. |
| Journal Title |
European Journal of Pediatrics
|
| ISSN | 03406199
14321076
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| NCID | AA00639676
AA11622857
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| Publisher | Springer Berlin Heidelberg
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| Volume | 176
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| Issue | 2
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| Start Page | 183
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| End Page | 189
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| Published Date | 2016-12-19
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| Remark | 内容要旨・審査要旨・論文本文の公開：
内容要旨・審査要旨：LID201704131003.pdf 論文本文： k3013_fulltext.pdf 本論文は, 著者Tomomasa Teradaの学位論文として提出され, 学位審査・授与の対象となっている。 The final publication is available at link.springer.com. |
| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
|
| TextVersion |
ETD
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| MEXT report number | 甲第3013号
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| Diploma Number | 甲医第1317号
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| Granted Date | 2017-03-23
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| Degree Name |
Doctor of Medical Science
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| Grantor |
Tokushima University
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| departments |
University Hospital
Medical Sciences
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