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ID 118599
Author
Sogabe, Masahiro Tokushima University|Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Okahisa, Toshiya Tokushima University|Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kagawa, Miwako Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers
Ueda, Hiroyuki Tokushima University|Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers
Kagemoto, Kaizo Tokushima University
Nakasono, Masahiko Tsurugi Municipal Handa Hospital
Keywords
Ages
Alcohol drinking
Onset
Liver diseases
Sex
Content Type
Journal Article
Description
Background & aims: The influence of changes in alcohol consumption on newly developed metabolic dysfunction-associated fatty liver disease (MAFLD) is unclear. We investigated the influence of alcohol consumption on newly developed MAFLD in both sexes.
Methods: This observational cohort study included 4071 patients who underwent more than two health check-ups between 2015 and 2020 over an interval of more than a year. Generalised estimating equations were used for analyses.
Results: At baseline, the rates of drinking and MAFLD between men and women were 72.5% versus 41.7% and 42.2% versus 22.1%, respectively. At the most recent stage, the rates of an increase in alcohol consumption for men and women were 13.3% and 8.7%, respectively, and 311/1192 (26.1%) men and 155/1566 (9.9%) women had newly developed MAFLD. The odds ratio (OR) for drinking in patients with newly developed MAFLD was 0.863 (men) (95% confidence interval [CI], 0.676-1.102, p = 0.237) and 1.041 (women) (95% CI, 0.753-1.439, p = 0.808); the OR for women who drank 140-279.9 g/week was 2.135 (95% CI, 1.158-3.939, p < 0.05) and that for all drinking categories among women was >1. Several non-invasive fibrosis scores were significantly associated with the quantity of alcohol consumption in patients with newly developed MAFLD (p < 0.005).
Conclusions: Alcohol consumption had no significant protective effect against newly developed MAFLD in both sexes, regardless of quantity. Conversely, alcohol consumption ≥140 g/week was a risk factor for newly developed MAFLD in women. The development of liver fibrosis with increased alcohol intake should be considered in patients with MAFLD.
Journal Title
Clinical Nutrition
ISSN
15321983
02615614
NCID
AA11544924
AA10643818
Publisher
Elsevier
Volume
42
Issue
5
Start Page
810
End Page
816
Published Date
2023-03-31
Rights
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
University Hospital