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ID 115033
Author
Takamura, Yoshihiro University of Fukui
Shimura, Masahiko Tokyo Medical University
Someya, Hideaki National Defense Medical College
Sugimoto, Masahiko Mie University
Hirano, Takao Shinshu University
Sakamoto, Taiji Kagoshima University
Gozawa, Makoto University of Fukui
Matsumura, Takehiro University of Fukui
Inatani, Masaru University of Fukui
Content Type
Journal Article
Description
Background/Aims
To investigate whether intravitreal injection of triamcinolone acetonide (IVTA) combined with vitrectomy prevents postoperative inflammation in patients with vitreous haemorrhage (VH) due to proliferative diabetic retinopathy (PDR).
Methods
This prospective, multicentre, randomised study conducted at seven sites in Japan enrolled patients diagnosed as having VH following PDR. Patients underwent vitrectomy with (IVTA+VIT group) or without (VIT group) IVTA at the end of the surgery. Anterior flare intensity (AFI), central retinal thickness (CRT), best-corrected visual acuity (BCVA) and intraocular pressure (IOP) were measured before and at 3 days, 1 week, 1, 3 and 6 months after surgery and compared.
Results
Number of patients who completed 6 months of follow-up was 40 and 41 in VIT group and IVTA+VIT group, respectively. AFI was significantly higher in the VIT group than in the IVTA+VIT group at 3 days (P=0.033), 1 week (P=0.019) and 1 month (P=0.037). There were no significant differences in CRT, BCVA and IOP between the groups through the observational periods. In the cases with macular oedema >350 µm of CRT at 3 days, CRT was significantly lower in the IVTA+VIT group than in the VIT group at 1 month (P=0.041).
Conclusions
IVTA combined with vitrectomy and cataract surgery contributed to inhibit the postoperative inflammation in patients with VH due to PDR. The effect of IVTA in the reduction of diabetic macular oedema may be limited to the early stage after surgery.
Journal Title
British Journal of Ophthalmology
ISSN
00071161
14682079
NCID
AA00574774
Publisher
BMJ Publishing Group
Volume
102
Issue
10
Start Page
1351
End Page
1357
Published Date
2018-01-17
Rights
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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DOI (Published Version)
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language
eng
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departments
University Hospital