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ID 115486
Author
Koyama, Teruhide Kyoto Prefectural University of Medicine
Kuriyama, Nagato Kyoto Prefectural University of Medicine
Ozaki, Etsuko Kyoto Prefectural University of Medicine
Matsui, Daisuke Kyoto Prefectural University of Medicine
Watanabe, Isao Kyoto Prefectural University of Medicine
Takeshita, Wakiko Kyoto Prefectural University of Medicine
Iwai, Komei Kyoto Prefectural University of Medicine
Watanabe, Yoshiyuki Kyoto Prefectural University of Medicine
Nakatochi, Masahiro Nagoya University
Shimanoe, Chisato Saga University
Tanaka, Keitaro Saga University
Oze, Isao Aichi Cancer Center Research Institute
Ito, Hidemi Aichi Cancer Center Research Institute
Ibusuki, Rie Kagoshima University
Shimoshikiryo, Ippei Kagoshima University
Takashima, Naoyuki Shiga University
Kadota, Aya Shiga University
Kawai, Sayo Nagoya University
Sasakabe, Tae Nagoya University
Okada, Rieko Nagoya University
Hishida, Asahi Nagoya University
Naito, Mariko Nagoya University
Kuriki, Kiyonori University of Shizuoka
Endoh, Kaori University of Shizuoka
Furusyo, Norihiro Kyushu University
Ikezaki, Hiroaki Kyushu University
Suzuki, Sadao Nagoya City University
Hosono, Akihiro Nagoya City University
Mikami, Haruo Chiba Cancer Center Research Institute
Nakamura, Yohko Chiba Cancer Center Research Institute
Kubo, Michiaki RIKEN
Wakai, Kenji Nagoya University
Keywords
Adrenomedullin
Receptor activity-modifying protein 2
Calcitonin-receptor-like receptor
Stroke
Content Type
Journal Article
Description
Aim: Stroke is associated closely with vascular homeostasis, and several complex processes and interacting pathways, which involve various genetic and environmental factors, contribute to the risk of stroke. Although adrenomedullin (ADM) has a number of physiological and vasoprotective functions, there are few studies of the ADM receptor system in humans. The ADM receptor comprises a calcitonin-receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs). We analyzed single nucleotide polymorphisms (SNPs) in the RAMP2 and CLR genes to determine their association with stroke in the light of gene-environment interactions.
Methods: Using cross-sectional data from the Japan Multi-Institutional Collaborative Cohort Study in the baseline surveys, 14,087 participants from 12 research areas were genotyped. We conducted a hypothesis-based association between stroke prevalence and SNPs in the RAMP2 and CLR genes based on data abstracted from two SNPs in RAMP2 and 369 SNPs in CLR. We selected five SNPs from among the CLR variants (rs77035639, rs3815524, rs75380157, rs574603859, and rs147565266) and one RAMP2 SNP (rs753152), which were associated with stroke, for analysis.
Results: Five of the SNPs (rs77035639, rs3815524, rs75380157, rs147565266, and rs753152) showed no significant association with obesity, ischemic heart disease, hypertension, dyslipidemia, and diabetes. In the logistic regression analysis, rs574603859 had a lower odds ratio (0.238; 95% confidence interval, 0.076–0.745, adjusted for age, sex, and research area) and the other SNPs had higher odds ratios for association with stroke.
Conclusions: This was the first study to investigate the relationships between ADM receptor genes (RAMP2 and CLR) and stroke in the light of gene-environment interactions in human.
Journal Title
Journal of Atherosclerosis and Thrombosis
ISSN
18803873
13403478
Publisher
Japan Atherosclerosis Society
Volume
24
Issue
12
Start Page
1267
End Page
1281
Published Date
2017-12-01
Rights
Copyright©2017 Japan Atherosclerosis Society
This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.(https://creativecommons.org/licenses/by-nc-sa/4.0/)
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language
eng
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departments
Medical Sciences