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ID 114712
Title Alternative
ヒト歯髄幹細胞由来培養上清による皮膚の放射線障害の抑制効果
Dental pulp stem cell factors for treating RISR
Author
Hibi, Hideharu Nagoya University
Keywords
human dental pulp stem cells
conditioned media
mesenchymal stem cells
radiation-induced skin reaction
cutaneous radiation syndrome
radiation-induced skin reactions
Content Type
Thesis or Dissertation
Description
Radiation-induced skin ulceration is a frequent complication of radiotherapy for cancer treatment. Stem cells from human exfoliated deciduous teeth (SHEDs) can regenerate various tissues. In this study, we investigated the impact of SHED-conditioned media (SHED-CM) on radiation-induced ulceration. Mouse necks were locally irradiated with a single dose of 15 Gy of radiation. A week after the irradiation, most of the wild-type mice generated ulcer surrounded by severe erythema. Intra-venous administration of SHED-CM effectively inhibited the ulcer formation. Histological examination revealed that SHED-CM treatment inhibited radiation-induced dermal thickness and epithelial hyperplasia. SHED-CM could be a useful treatment option for radiation-induced skin ulceration.
Journal Title
Journal of Oral Health and Biosciences
ISSN
21896682
Publisher
Shikoku Society of Dental Research
Volume
33
Issue
1
Start Page
1
End Page
7
Sort Key
1
Published Date
2020-06-12
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Keita Kawarabayashiの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3382号
Diploma Number
甲口第461号
Granted Date
2020-03-23
Degree Name
Doctor of Dental Science
Grantor
Tokushima University
departments
Oral Sciences