number of access : ?
number of downloads : ?
ID 114401
Author
Obata, Fumiaki Tokushima University
Matsuura, Motokazu Tokushima Red Cross Hospital KAKEN Search Researchers
Kishi, Fumi Tokushima University
Keywords
Light Chain Proximal Tubulopathy (LCPT)
IgD λ myeloma
paraprotein related kidney disease
Content Type
Journal Article
Description
Light Chain Proximal Tubulopathy (LCPT) is a rare form of paraprotein-related kidney disease in which monoclonal free light chains damage the proximal renal tubular epithelial cells. We herein report the case of a 78-year-old woman who presented with anemia and kidney dysfunction. Serum and urine protein electrophoresis analyses revealed a monoclonal IgD and λ free light chains. Proximal tubular injury and the accumulation of λ light chains were found by kidney biopsy. Electron microscopy revealed no organized structure suggestive of crystals. LCPT was caused by IgD lambda myeloma and bortezomib and dexamethasone therapy led to very good partial response (VGPR) without a worsening of the kidney function.
Journal Title
Internal Medicine
ISSN
13497235
Publisher
The Japanese Society of Internal Medicine
Volume
57
Issue
24
Start Page
3597
End Page
3602
Published Date
2018-12-15
Rights
The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Medical Sciences