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ID 116504
Title Alternative
monosodium glutamate increases T1R3 expression
Author
Beppu, Kana Tokushima University
Shono, Hitoshi Tokushima University
Kawakami, Ayuka Tokushima University
Takashi, Tomoe Tokushima University
Watanabe, Suzuno Tokushima University
Yoshida, Akari Tokushima University
Fujimoto, Chisa Tokushima University
Ohnishi, Hiroki Tokushima University
Keywords
monosodium glutamate (MSG)
taste 1 receptor 3 (T1R3)
dysgeusia
Content Type
Journal Article
Description
We previously showed that chemotherapy-induced dysgeusia was associated with lingual taste receptor gene expression, and monosodium glutamate (MSG) improved dysgeusia by upregulating taste 1 receptor 3 (T1R3) gene expression. In recent years, decreased taste sensitivity has also been reported in some young people, and these are partly due to their disordered eating habits. From these background, we investigated the effects of MSG supplementation on taste receptor expression and dietary intake in healthy females. Fifteen young healthy volunteers were enrolled for the present crossover study and divided in two groups (dietary supplementation with MSG at 2.7 g / day or 0.27 g / day). The relative expression of T1R3, a subunit of both umami and sweet taste receptors, in the tongue was assessed by quantitative PCR analysis. Food intake was assessed by food frequency questionnaire (FFQg), and body composition was measured using Omron HBF-701. T1R3 expression levels in the tongue and taste sensitivity increased significantly in participants who consumed <10 g of MSG daily, whereas no alteration was observed in participants who consumed >10 g of MSG daily. Furthermore, protein, fat, and carbohydrate (PFC) balance and salt and sugar intake improved by MSG supplementation. In conclusion, MSG supplementation increased T1R3 expression in the tongue and improved dietary balance.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
68
Issue
3-4
Start Page
315
End Page
320
Sort Key
315
Published Date
2021-08
Remark
著者名英表記誤記あり (誤)Takahito Azuma→(正)Takahiro Azuma
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
University Hospital