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ID 115106
Author
Content Type
Journal Article
Description
We have constructed two human immunodeficiency type 1 (HIV-1) derivatives, CXCR4 tropic and CCR5 tropic, that replicate in rhesus macaques. They are genetically engineered to be resistant to macaque restriction factors against HIV-1, including TRIM5α, APOBEC3, and tetherin proteins. The two HIV-1 variants described here are fundamental clones aiming for rhesus infection studies of HIV-1.
Journal Title
Genome Announcements
Publisher
American Society for Microbiology
Volume
5
Issue
39
Start Page
e01063-17
Published Date
2017-09-28
Rights
© 2017 Nomaguchi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license(https://creativecommons.org/licenses/by/4.0/).
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DOI (Published Version)
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language
eng
TextVersion
Publisher
departments
Medical Sciences