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ID 117809
Title Alternative
Novel Lipid Risk Stratification for CAD
Author
Abe, Shichiro Dokkyo Medical University
Haruyama, Yasuo Dokkyo Medical University
Kobashi, Gen Dokkyo Medical University
Toyoda, Shigeru Dokkyo Medical University
Inoue, Teruo Dokkyo Medical University|Nasu Red Cross Hospital
Tomiyama, Hirofumi Tokyo Medical University
Ishizu, Tomoko University of Tsukuba
Kohro, Takahide Jichi Medical University
Higashi, Yukihito Research Institute for Radiation Biology and Medicine
Takase, Bonpei National Defense Medical College Research Institute
Suzuki, Toru University of Leicester
Ueda, Shinichiro University of the Ryukyus
Yamazaki, Tsutomu The University of Tokyo
Furumoto, Tomoo NTT Medical Center Sapporo
Kario, Kazuomi Jichi Medical University
Koba, Shinji Showa University
Takemoto, Yasuhiko Osaka City University
Hano, Takuzo Wakayama Medical University
Ishibashi, Yutaka Shimane University
Node, Koichi Saga University
Maemura, Koji Nagasaki University
Ohya, Yusuke University of the Ryukyus
Furukawa, Taiji Teikyo University
Ito, Hiroshi Okayama University
Yamashina, Akira Tokyo Medical University
Keywords
Coronary artery disease
Flow-mediated dilation
Lipid risk stratification
Non-high-density lipoprotein cholesterol
Triglyceride
Content Type
Journal Article
Description
Background: Elevated levels of triglyceride (TG) and non-high-density lipoprotein cholesterol (non-HDL-C) are regarded as a residual lipid risk in low-density lipoprotein cholesterol (LDL-C)-lowering therapy. This study investigated the association between lipid risk stratified by TG and non-HDL-C and the prognosis of patients with coronary artery disease (CAD), and the association between stratified lipid risk and flow-mediated dilatation (FMD) index.
Methods and Results: The 624 CAD patients enrolled in flow-mediated dilation (FMD)-J study A were divided into 4 groups: low-risk group (n=413) with TG <150 mg/dL and non-HDL-C <170 mg/dL; hyper-TG group (n=180) with TG ≥150 mg/dL and non-HDL-C <170 mg/dL; hyper-non-HDL group (n=12) with TG <150 mg/dL and non-HDL-C ≥170 mg/dL; and high-risk group (n=19) with TG ≥150 mg/dL and non-HDL-C ≥170 mg/dL. Comparison of the groups showed the cumulative incidence of a 3-point major adverse cardiovascular event (MACE) was different and highest in the high-risk group in all the patients (P=0.009), and in patients with a FMD index ≥7.0% (P=0.021), but not in those with a FMD index <7.0%. Multivariable regression analysis showed that high lipid risk (P=0.019) and FMD <7.0% (P=0.040) were independently correlated with the incidence of a 3-point MACE.
Conclusions: Novel stratification of lipid risk, simply using TG and non-HDL-C levels, combined with FMD measurement, is useful for predicting cardiovascular outcomes in patients with CAD.
Journal Title
Circulation Journal
ISSN
13474820
Publisher
The Japanese Circulation Society
Volume
86
Issue
9
Start Page
1444
End Page
1454
Published Date
2022-08-25
Rights
This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license. https://creativecommons.org/licenses/by-nc-nd/4.0/
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DOI (Published Version)
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language
eng
TextVersion
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departments
Medical Sciences